Receptor binding in dopa-responsive dystonia

Gabriella Künig, Klaus L. Leenders, Angelo Antonini, Peter Vontobel, Adolf Weindl, Hans M. Meinck

Research output: Contribution to journalArticle

Abstract

We have studied dopamine D2 receptor binding by [11C]raclopride positron emission tomography in 14 patents with dopa-responsive dystonia (DRD). Data were compared with 16 levodopa-treated patients with Parkinson's disease (PD) and 26 healthy controls. The results revealed an elevated [11C]raclopride binding index in the putamen and caudate nucleus of DRD patients compared with controls as well as a significant elevation in the candate nucleus compared with PD patients. The increase of [11C]raclopride binding may be interpreted either as reduced tracer displacement by endogenous dopamine, or as an alteration of the receptor features due to chronic dopamine deficiency. The difference in [11C]raclopride binding in DRD and PD patients in the caudate nucleus suggests that this structure may be of pathophysiological relevance in the presentation of the clinical features of both diseases.

Original languageEnglish
Pages (from-to)758-762
Number of pages5
JournalAnnals of Neurology
Volume44
Issue number5
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Künig, G., Leenders, K. L., Antonini, A., Vontobel, P., Weindl, A., & Meinck, H. M. (1998). Receptor binding in dopa-responsive dystonia. Annals of Neurology, 44(5), 758-762.