Receptor imaging with 111In-pentreotide and 123I-methoxybenzamide, and inhibition tests with octreotide and bromocriptine of mixed growth hormone/prolactin-secreting pituitary tumors

N. Panza, P. F. Rambaldi, C. Battista, G. Ambrosio, G. L. Cascini, F. Schillirò, L. Mansi

Research output: Contribution to journalArticle

Abstract

We have performed pituitary scintigraphy with 111In-pentreotide (OCT), a somatostatin analogue, and with metoxybenzamide (IBZM) by 123I- IBZM in two patients affected by mixed growth hormone/prolactin-secreting pituitary tumors. Short-term growth hormone (GH) inhibition by a single injection of OCT (100 μg sc), and short-term prolactin (PRL) inhibition by oral administration of 2.5 mg of bromocriptine (BCR), were also performed in both patients. The first patient, a 26 year old man, showed intense tumor uptake of 123I-IBZM scintigraphy, whereas 111In-OCT scintigraphy showed moderate tumor uptake. Five hours after the BCR inhibition test, a fall of 83% in PRL plasma levels (from 8,336 μg/L to 1,417 μg/L), and of 91.6% in GH plasma levels (from 39.5 μg/L to 3.3 μg/L) were observed. OCT inhibition test suppressed GH plasma levels from 36 μg/L to 3.5 μg/L. The patient was submitted to treatment with BCR and OCT. A dramatic shrinkage of the tumor was seen after six months of therapy. The lesion disappeared one year after the start of therapy. The second patient, a 64 year old man, showed intense uptake at 111In-OCT scintigraphy, while 123I-IBZM uptake was not observed. A test dose of BCR resulted in an acute fall of PRL (from 145 μg/L to 118 μg/L), but not of GH. A test dose of OCT decreased the GH plasma level from 61 μg/L to 4.5 μg/L. The patient was submitted to treatment with BCR and OCT that resulted in a computed tomography and magnetic resonance imaging decrease of 45% of tumor volume one year after the start of therapy. Our results suggest that both suppression tests with OCT and BCR, and scintigraphic studies in vivo with 123I-IBZM and 111In-OCT can be predictive for the effectiveness of therapies with dopamine agonists and/or SS-analogs in patients with mixed PRL/GH-secreting pituitary tumors. Further studies are required to evaluate the role of suppressive tests in selecting patients for appropriate clinical treatments.

Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalBiomedicine and Pharmacotherapy
Volume53
Issue number7
DOIs
Publication statusPublished - Aug 1999

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Octreotide
Bromocriptine
Pituitary Neoplasms
Prolactin
Growth Hormone
Radionuclide Imaging
Therapeutics
Neoplasms
Dopamine Agonists
Somatostatin
Tumor Burden
Oral Administration
Tomography
Magnetic Resonance Imaging
3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide
Injections

Keywords

  • Bromocruptine
  • IBZM
  • Octreotide
  • Pituitary tumors

ASJC Scopus subject areas

  • Pharmacology

Cite this

Receptor imaging with 111In-pentreotide and 123I-methoxybenzamide, and inhibition tests with octreotide and bromocriptine of mixed growth hormone/prolactin-secreting pituitary tumors. / Panza, N.; Rambaldi, P. F.; Battista, C.; Ambrosio, G.; Cascini, G. L.; Schillirò, F.; Mansi, L.

In: Biomedicine and Pharmacotherapy, Vol. 53, No. 7, 08.1999, p. 319-322.

Research output: Contribution to journalArticle

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abstract = "We have performed pituitary scintigraphy with 111In-pentreotide (OCT), a somatostatin analogue, and with metoxybenzamide (IBZM) by 123I- IBZM in two patients affected by mixed growth hormone/prolactin-secreting pituitary tumors. Short-term growth hormone (GH) inhibition by a single injection of OCT (100 μg sc), and short-term prolactin (PRL) inhibition by oral administration of 2.5 mg of bromocriptine (BCR), were also performed in both patients. The first patient, a 26 year old man, showed intense tumor uptake of 123I-IBZM scintigraphy, whereas 111In-OCT scintigraphy showed moderate tumor uptake. Five hours after the BCR inhibition test, a fall of 83{\%} in PRL plasma levels (from 8,336 μg/L to 1,417 μg/L), and of 91.6{\%} in GH plasma levels (from 39.5 μg/L to 3.3 μg/L) were observed. OCT inhibition test suppressed GH plasma levels from 36 μg/L to 3.5 μg/L. The patient was submitted to treatment with BCR and OCT. A dramatic shrinkage of the tumor was seen after six months of therapy. The lesion disappeared one year after the start of therapy. The second patient, a 64 year old man, showed intense uptake at 111In-OCT scintigraphy, while 123I-IBZM uptake was not observed. A test dose of BCR resulted in an acute fall of PRL (from 145 μg/L to 118 μg/L), but not of GH. A test dose of OCT decreased the GH plasma level from 61 μg/L to 4.5 μg/L. The patient was submitted to treatment with BCR and OCT that resulted in a computed tomography and magnetic resonance imaging decrease of 45{\%} of tumor volume one year after the start of therapy. Our results suggest that both suppression tests with OCT and BCR, and scintigraphic studies in vivo with 123I-IBZM and 111In-OCT can be predictive for the effectiveness of therapies with dopamine agonists and/or SS-analogs in patients with mixed PRL/GH-secreting pituitary tumors. Further studies are required to evaluate the role of suppressive tests in selecting patients for appropriate clinical treatments.",
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AU - Battista, C.

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AU - Mansi, L.

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