Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain

Ferdinando Nicoletti, Pier Luigi Canonico, Antonella Favit, Giovanni Nicoletti, Vincenzo Albanese

Research output: Contribution to journalArticle

Abstract

Stimulation of inositol phospolipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositolmonophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.

Original languageEnglish
Pages (from-to)299-301
Number of pages3
JournalEuropean Journal of Pharmacology
Volume160
Issue number2
DOIs
Publication statusPublished - Jan 31 1989

Keywords

  • Brain (human)
  • Carbachol
  • Inositol phospholipids
  • Norepinephrine
  • Quisqualate

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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