Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain

Ferdinando Nicoletti, Pier Luigi Canonico, Antonella Favit, Giovanni Nicoletti, Vincenzo Albanese

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Stimulation of inositol phospolipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositolmonophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.

Original languageEnglish
Pages (from-to)299-301
Number of pages3
JournalEuropean Journal of Pharmacology
Volume160
Issue number2
DOIs
Publication statusPublished - Jan 31 1989

Fingerprint

Phosphatidylinositols
Hydrolysis
Quisqualic Acid
Excitatory Amino Acid Agonists
Cholinergic Agonists
Muscarinic Agonists
Occipital Lobe
Cerebellar Cortex
Neurotransmitter Receptor
Glutamate Receptors
Brain
Carbachol
Inositol
Temporal Lobe
Brain Neoplasms
Norepinephrine

Keywords

  • Brain (human)
  • Carbachol
  • Inositol phospholipids
  • Norepinephrine
  • Quisqualate

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain. / Nicoletti, Ferdinando; Canonico, Pier Luigi; Favit, Antonella; Nicoletti, Giovanni; Albanese, Vincenzo.

In: European Journal of Pharmacology, Vol. 160, No. 2, 31.01.1989, p. 299-301.

Research output: Contribution to journalArticle

Nicoletti, Ferdinando ; Canonico, Pier Luigi ; Favit, Antonella ; Nicoletti, Giovanni ; Albanese, Vincenzo. / Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain. In: European Journal of Pharmacology. 1989 ; Vol. 160, No. 2. pp. 299-301.
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