Assetto recettoriale (ER e PgR) determinato con metodo immunoistochimico e biochimico nel carcinoma mammario.

Translated title of the contribution: Receptor status (ER and PgR) determined with histochemical and biochemical methods in breast carcinoma

G. Simone, A. Paradiso, R. Cirillo, A. Mangia, G. Rella, S. Wiesel, S. Petroni, G. De Benedictis, M. De Lena

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, a method similar to ER.ICA has been proposed for the progesterone receptor (PgR) using two monoclonal antibodies, JZB39 and KD68, specific for human PgR and characterized by a molecular weight of 95 and 120 Kd, respectively. A series of 73 breast cancer patients was studied with regards to ER and PgR using both immunocytochemical (ICA) and biochemical (DCC) assays. Results showed no substantial differences between the two methods when considering common clinical-pathological parameters. Overall agreement between ICA and DCC methods was found: 79% for PgR and 78% for ER. A slight quantitative correlation was also observed between the "score values" of the ICA method and the Fmol content of ER and PgR using the Brave-Pearson test (r = 0.49 for PgR; r = 0.43 for ER). Specificity of PgR.ICA method was 77% for PgR and 72% for ER; sensitivity was 82% and 83%, respectively. The ICA method is a reliable technique to assess PgR presence as well as ER. Further studies are necessary to evaluate the prognostic role of nuclear PgR.

Translated title of the contributionReceptor status (ER and PgR) determined with histochemical and biochemical methods in breast carcinoma
Original languageItalian
Pages (from-to)449-459
Number of pages11
JournalPathologica
Volume83
Issue number1086
Publication statusPublished - Jul 1991

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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