Receptors for IgM are expressed on acute lymphoblastic leukemic cells having T-cell characteristics

Lorenzo Moretta, Maria C. Mingari, Alessandro Moretta, Peter M. Lydyard

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Six acute lymphoblastic leukemia (ALL) patients were studied whose lymphoblasts formed rosettes with sheep erythrocytes to determine if they expressed a receptor for IgM, which is a characteristics of normal T cells; chronic lymphocytic leukemia (CLL) cases carrying B-cell markers were compared as controls. In all six cases of ALL, but not CLL, IgM was expressed after overnight incubation in tissue culture medium. It is therefore considered that the IgM receptor can be used as an additional reliable marker for classifying leukemic disorders.

Original languageEnglish
Pages (from-to)405-409
Number of pages5
JournalClinical Immunology and Immunopathology
Volume7
Issue number3
DOIs
Publication statusPublished - 1977

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Immunoglobulin M
B-Cell Chronic Lymphocytic Leukemia
T-Lymphocytes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Culture Media
Sheep
B-Lymphocytes
Erythrocytes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Receptors for IgM are expressed on acute lymphoblastic leukemic cells having T-cell characteristics. / Moretta, Lorenzo; Mingari, Maria C.; Moretta, Alessandro; Lydyard, Peter M.

In: Clinical Immunology and Immunopathology, Vol. 7, No. 3, 1977, p. 405-409.

Research output: Contribution to journalArticle

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