Large granular lymphocytes (LGL) are nonadherent cells with cytoplasmic azurophilic granules, avid receptors and the Fc portion of IgG, and a paranuclear localization of alpha-naphthyl acid esterase or acid phosphatase. LGL constitute the bulk of T(G) cells (cells with receptors for sleep erythrocytes and for IgG molecules) and null cells (non-T, non-B cells). In the present study we demonstrate that 20-33% of the circulating human LGL express receptors for the third complement component (C3R). When T(G) cell or null cell fractions from normal individuals or non-T cells from a patient with infantile agam aglobulinaemia (which contained almost exclusively LGL) were rosettes with erythrocytes coated with antibody and complement, a variable number of C3R-bearing cells were detected. Such cells were isolated and analysed further; the great majority of them displayed the cytochemical and ultrastructural features of LGL.
|Number of pages||7|
|Journal||Scandinavian Journal of Immunology|
|Publication status||Published - 1982|
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