Receptors for thymosin alpha 1 on mouse thymocytes

Cristina Rinaldi Garaci; Maria Rosaria Torrisi; Teresa Jezzi; Luigi Frati; Allan L. Goldstein; Enrico Garaci

doi:10.1016/0008-8749(85)90051-6

Receptors for thymosin alpha 1 on mouse thymocytes

Cristina Rinaldi Garaci, Maria Rosaria Torrisi, Teresa Jezzi, Luigi Frati, Allan L. Goldstein, Enrico Garaci

Research output: Contribution to journal › Article

Abstract

Thymosin α₁, is able to act in vitro to stimulate T-cell precursors and to induce surface markers. The initial mechanism by which α₁ activates T cells could be the binding of α₁ to cell membranes. Using a specific anti-α₁ antibody and an indirect immunofluorescence procedure it was found that thymosin α₁ binds to the surface of a large portion of murine lymphocytes. Furthermore, thymocytes have been fractionated into immature and mature subpopulations by using the peanut agglutinin (PNA) technique. It was found that PNA⁺, immature cells showed specific receptors for α₁ on the cell membrane.

Original language	English
Pages (from-to)	289-293
Number of pages	5
Journal	Cellular Immunology
Volume	91
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(85)90051-6
Publication status	Published - 1985

ASJC Scopus subject areas

Cell Biology
Immunology

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Garaci, C. R., Torrisi, M. R., Jezzi, T., Frati, L., Goldstein, A. L., & Garaci, E. (1985). Receptors for thymosin alpha 1 on mouse thymocytes. Cellular Immunology, 91(1), 289-293. https://doi.org/10.1016/0008-8749(85)90051-6

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abstract = "Thymosin α1, is able to act in vitro to stimulate T-cell precursors and to induce surface markers. The initial mechanism by which α1 activates T cells could be the binding of α1 to cell membranes. Using a specific anti-α1 antibody and an indirect immunofluorescence procedure it was found that thymosin α1 binds to the surface of a large portion of murine lymphocytes. Furthermore, thymocytes have been fractionated into immature and mature subpopulations by using the peanut agglutinin (PNA) technique. It was found that PNA+, immature cells showed specific receptors for α1 on the cell membrane.",

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AU - Garaci, Cristina Rinaldi

AU - Torrisi, Maria Rosaria

AU - Jezzi, Teresa

AU - Frati, Luigi

AU - Goldstein, Allan L.

AU - Garaci, Enrico

PY - 1985

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AB - Thymosin α1, is able to act in vitro to stimulate T-cell precursors and to induce surface markers. The initial mechanism by which α1 activates T cells could be the binding of α1 to cell membranes. Using a specific anti-α1 antibody and an indirect immunofluorescence procedure it was found that thymosin α1 binds to the surface of a large portion of murine lymphocytes. Furthermore, thymocytes have been fractionated into immature and mature subpopulations by using the peanut agglutinin (PNA) technique. It was found that PNA+, immature cells showed specific receptors for α1 on the cell membrane.

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