Receptors for thymosin alpha 1 on mouse thymocytes

Cristina Rinaldi Garaci, Maria Rosaria Torrisi, Teresa Jezzi, Luigi Frati, Allan L. Goldstein, Enrico Garaci

Research output: Contribution to journalArticle

Abstract

Thymosin α1, is able to act in vitro to stimulate T-cell precursors and to induce surface markers. The initial mechanism by which α1 activates T cells could be the binding of α1 to cell membranes. Using a specific anti-α1 antibody and an indirect immunofluorescence procedure it was found that thymosin α1 binds to the surface of a large portion of murine lymphocytes. Furthermore, thymocytes have been fractionated into immature and mature subpopulations by using the peanut agglutinin (PNA) technique. It was found that PNA+, immature cells showed specific receptors for α1 on the cell membrane.

Original languageEnglish
Pages (from-to)289-293
Number of pages5
JournalCellular Immunology
Volume91
Issue number1
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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    Garaci, C. R., Torrisi, M. R., Jezzi, T., Frati, L., Goldstein, A. L., & Garaci, E. (1985). Receptors for thymosin alpha 1 on mouse thymocytes. Cellular Immunology, 91(1), 289-293. https://doi.org/10.1016/0008-8749(85)90051-6