Thymosin α1, is able to act in vitro to stimulate T-cell precursors and to induce surface markers. The initial mechanism by which α1 activates T cells could be the binding of α1 to cell membranes. Using a specific anti-α1 antibody and an indirect immunofluorescence procedure it was found that thymosin α1 binds to the surface of a large portion of murine lymphocytes. Furthermore, thymocytes have been fractionated into immature and mature subpopulations by using the peanut agglutinin (PNA) technique. It was found that PNA+, immature cells showed specific receptors for α1 on the cell membrane.
ASJC Scopus subject areas
- Cell Biology