Receptors, signal transduction, and spectrum of action of monocyte chemotactic protein-1 and related chemokines

S. Sozzani, M. Locati, D. Zhou, M. Rieppi, W. Luini, G. Lamorte, G. Bianchi, N. Polentarutti, P. Allavena, A. Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

Chemokines are a bipartite family of chemotactic proteins that bear the structural hallmark of four cysteine residues, the first two of which are in tandem, The spectrum of action of C-C chemokines, monocyte chemotactic protein-1 (MCP-1), MCP-2, and MCP-3, in particular, encompasses, in addition to monocytes, other leukocyte populations, Evidence is presented that MCP-1, MCP-2, and MCP-3 are active on natural killer cells, Available information on receptor usage by MCP-1 and related chemokines and signal transduction pathways is reviewed, A better understanding of signaling mechanisms will provide a new basis for therapeutic strategies.

Original languageEnglish
Pages (from-to)788-794
Number of pages7
JournalJournal of Leukocyte Biology
Volume57
Issue number5
Publication statusPublished - 1995

Keywords

  • Calcium
  • Natural killer cells
  • Phospholipase A
  • Second messengers
  • T lymphocytes

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Receptors, signal transduction, and spectrum of action of monocyte chemotactic protein-1 and related chemokines'. Together they form a unique fingerprint.

Cite this