Abstract
Novel variable (V)-joining (J) gene rearrangements are described in the human T cell receptor gamma locus, in which, on the one hand, the V3 variable gene is joined to the heptamer-nonamer recombination signals of the J1 segment and, on the other hand, the J1 segment is joined to the V3 recombination signals through head-to-head fusion. These recombination products, or hybrid joints, have been originated through an inversion of 47 kb DNA. Interestingly the inverted DNA stretch contains a normal V9-JP rearrangement. These findings are the first direct demonstration that successive rearrangements occur, on the same chromosome, in the human T cell receptor gamma locus, and suggest that the chronology of the joining events plays a role in the ontogeny of T cells and their differentiation in γ/δ+ and α/β+ lineages.
Original language | English |
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Pages (from-to) | 973-982 |
Number of pages | 10 |
Journal | International Immunology |
Volume | 3 |
Issue number | 10 |
Publication status | Published - 1991 |
Keywords
- gamma chain
- inversion
- recombinase
- recombination signals
- T cell receptor
- variable genes
ASJC Scopus subject areas
- Immunology