RECIST 1.1 criteria predict recurrence-free survival in advanced ovarian cancer submitted to neoadjuvant chemotherapy

Giorgio Bogani, Laura Matteucci, Stefano Tamberi, Antonino Ditto, Ilaria Sabatucci, Ferdinando Murgia, Valentina Arcangeli, Giuseppa Maltese, Giuseppe Comerci, Marco Stefanetti, Cristina Sonetto, Giuseppina Calareso, Alfonso Marchiano, Valentina Chiappa, Domenica Lorusso, Francesco Raspagliesi

Research output: Contribution to journalArticle

Abstract

Objective: Neoadjuvant chemotherapy plus interval debulking surgery is growing treatment strategy for advanced ovarian cancer patients with unresectable disease. Here, we aimed to assess predictors of surgical unresectability and survival of patients submitted to neoadjuvant chemotherapy plus interval debulking surgery. Methods: Data of consecutive 193 patients undergoing neoadjuvant chemotherapy plus interval debulking surgery were retrospectively evaluated in four Italian oncologic centers. RECIST 1.1 guidelines were used to assess response to neoadjuvant chemotherapy. Survival outcomes were evaluated using Kaplan-Meier and Cox proportional hazard models. Results: Overall, 155 (80.3%) and 38 (19.7%) patients had optimal and non-optimal cytoreduction at the time of interval debulking surgery. Via multivariate analysis, age (OR: 2.87 (95%CI: 1.29, 6.36) per 10-year increase) and radiological response to neoadjuvant chemotherapy (OR: 48.1 (95%CI: 6.33, 365.3)) impact on the inability to perform a complete cytoreduction. Patients having complete or partial response experienced a significant better disease-free survival than patients having stable or progressive disease at radiological examination (median disease-free survival 16.8 vs. 11.0 months; HR: 0.42 (95%CI: 0.09, 0.78); p =.001). Radiological response did not predict for overall survival (p =.719). Conclusions: RECIST1.1 response criteria might be helpful to predict surgical resectability and disease-free survival of advanced stage ovarian cancer patients undergoing neoadjuvant chemotherapy plus interval debulking surgery.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume237
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Interval debulking surgery
  • Neoadjuvant chemotherapy
  • Ovarian cancer
  • RECIST
  • Response

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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