Reclassification of oligoastrocytomas by loss of heterozygosity studies

Marica Eoli, Lorena Bissola, Maria Grazia Bruzzone, Bianca Pollo, Carmelo Maccagnano, Tiziana De Simone, Lorella Valletta, Antonio Silvani, D. Bianchessi, Giovanni Broggi, Amerigo Boiardi, Gaetano Finocchiaro

Research output: Contribution to journalArticle

Abstract

Oligoastrocytomas (OAs) are WHO grade II or III tumors composed of a mixture of 2 neoplastic cell types morphologically resembling the cells in oligodendrogliomas and diffuse astrocytomas. Investigations on the genetic profile of OAs may yield important information for their classification and help for their clinical management. We have studied, in 94 OAs (46 WHO grade II and 48 WHO grade III), the patterns of loss of heterozygosity (LOH) of 4 genomic regions: 1p, 19q, 17p and 10q. Results were as follows: LOH 1p was present in 46% of the tumors; LOH 19q in 45%; LOH 17p in 22%; LOH 10q in 16%. LOH 1p and 19q were associated in 32%, other LOH associations were rare (

Original languageEnglish
Pages (from-to)84-90
Number of pages7
JournalInternational Journal of Cancer
Volume119
Issue number1
DOIs
Publication statusPublished - Jul 1 2006

Keywords

  • LOH 10
  • LOH 17p
  • LOH 19q
  • LOH 1p
  • MRI
  • Oligoastrocytoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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