Recognition memory and prefrontal cortex: Dissociating recollection and familiarity processes using rTMS

Patrizia Turriziani, Massimiliano Oliveri, Silvia Salerno, Floriana Costanzo, Giacomo Koch, Carlo Caltagirone, Giovanni Augusto Carlesimo

Research output: Contribution to journalArticlepeer-review

Abstract

Recognition memory can be supported by both the assessment of the familiarity of an item and by the recollection of the context in which an item was encountered. The neural substrates of these memory processes are controversial. To address these issues we applied repetitive transcranial magnetic stimulation (rTMS) over the right and left dorsolateral prefrontal cortex (DLPFC) of healthy subjects performing a remember/know task. rTMS disrupted familiarity judgments when applied before encoding of stimuli over both right and left DLPFC. rTMS disrupted recollection when applied before encoding of stimuli over the right DLPFC. These findings suggest that the DLPFC plays a critical role in recognition memory based on familiarity as well as recollection.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalBehavioural Neurology
Volume19
Issue number1-2
Publication statusPublished - 2008

Keywords

  • Familiarity
  • Prefrontal cortex
  • Recognition memory
  • Recollection

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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