Recognition of antigenic clusters of Candida albicans by T lymphocytes from human immunodeficiency virus-infected persons

Annalisa Kunkl, Lorenzo Mortara, Maria Teresa Valle, Daniela Fenoglio, Maria Paola Terranova, Anna Maria Megiovanni, Anna Alessandrini, Giuseppina Li Pira, Giovanni Mazzarello, Valerio Del Bono, Andrea Canessa, Dante Bassetti, Fabrizio Manca

Research output: Contribution to journalArticle

Abstract

The fine specificity of the cellular immune response to Candida albicans (i.e., recognition of different antigenic components) between normal controls and human immunodeficiency virus-infected patients in various stages of disease was compared. C. albicans-specific T cells, enriched by antigen stimulation and interleukin-2 expansion, were challenged with antigenic fractions of different molecular weight obtained by SDS-gel fractionation of C. albicans extracts in the presence of autologous mononuclear cells as antigen-presenting cells. Proliferative responses showed similar patterns of reactivity between controls and category A and B seropositive subjects. Category C patients with concurrent C. albicans infections did not give rise to C. albicans-specific T cell lines, confirming the T cell defect. Patients without clinically evident C. albicans infection had a low but broad reactivity pattern of C. albicans-specific T cells. These results suggest that depletion of C. albicans-specific T cells, independent of their fine specificity, occurs along with disease progression.

Original languageEnglish
Pages (from-to)488-496
Number of pages9
JournalJournal of Infectious Diseases
Volume178
Issue number2
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    Kunkl, A., Mortara, L., Valle, M. T., Fenoglio, D., Terranova, M. P., Megiovanni, A. M., Alessandrini, A., Pira, G. L., Mazzarello, G., Del Bono, V., Canessa, A., Bassetti, D., & Manca, F. (1998). Recognition of antigenic clusters of Candida albicans by T lymphocytes from human immunodeficiency virus-infected persons. Journal of Infectious Diseases, 178(2), 488-496.