Recognition of the neural chemoattractant netrin-1 by integrins α6β4 and α3β1 regulates epithelial cell adhesion and migration

Mayra Yebra, Anthony M P Montgomery, Giuseppe R. Diaferia, Thomas Kaido, Steve Silletti, Brandon Perez, Margaret L. Just, Simone Hildbrand, Rosemary Hurford, Elin Florkiewicz, Marc Tessier-Lavigne, Vincenzo Cirulli

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

Netrins, axon guidance cues in the CNS, have also been detected in epithelial tissues. In this study, using the embryonic pancreas as a model system, we show that Netrin-1 is expressed in a discrete population of epithelial cells, localizes to basal membranes, and specifically associates with elements of the extracellular matrix. We demonstrate that α6β4 integrin mediates pancreatic epithelial cell adhesion to Netrin-1, whereas recruitment of α6β4 and α3β1 regulate the migration of CK19+/PDX1+ putative pancreatic progenitors on Netrin-1. These results provide evidence for the activation of epithelial cell adhesion and migration by a neural chemoattractant, and identify Netrin-1/integrin interactions as adhesive/guidance cues for epithelial cells.

Original languageEnglish
Pages (from-to)695-707
Number of pages13
JournalDevelopmental Cell
Volume5
Issue number5
DOIs
Publication statusPublished - Nov 2003

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Chemotactic Factors
Cell adhesion
Cell Adhesion
Integrins
Cell Movement
Epithelial Cells
Cues
Adhesives
Extracellular Matrix
Pancreas
Epithelium
Chemical activation
Tissue
Membranes
netrin-1
Recognition (Psychology)
Population

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Recognition of the neural chemoattractant netrin-1 by integrins α6β4 and α3β1 regulates epithelial cell adhesion and migration. / Yebra, Mayra; Montgomery, Anthony M P; Diaferia, Giuseppe R.; Kaido, Thomas; Silletti, Steve; Perez, Brandon; Just, Margaret L.; Hildbrand, Simone; Hurford, Rosemary; Florkiewicz, Elin; Tessier-Lavigne, Marc; Cirulli, Vincenzo.

In: Developmental Cell, Vol. 5, No. 5, 11.2003, p. 695-707.

Research output: Contribution to journalArticle

Yebra, M, Montgomery, AMP, Diaferia, GR, Kaido, T, Silletti, S, Perez, B, Just, ML, Hildbrand, S, Hurford, R, Florkiewicz, E, Tessier-Lavigne, M & Cirulli, V 2003, 'Recognition of the neural chemoattractant netrin-1 by integrins α6β4 and α3β1 regulates epithelial cell adhesion and migration', Developmental Cell, vol. 5, no. 5, pp. 695-707. https://doi.org/10.1016/S1534-5807(03)00330-7
Yebra, Mayra ; Montgomery, Anthony M P ; Diaferia, Giuseppe R. ; Kaido, Thomas ; Silletti, Steve ; Perez, Brandon ; Just, Margaret L. ; Hildbrand, Simone ; Hurford, Rosemary ; Florkiewicz, Elin ; Tessier-Lavigne, Marc ; Cirulli, Vincenzo. / Recognition of the neural chemoattractant netrin-1 by integrins α6β4 and α3β1 regulates epithelial cell adhesion and migration. In: Developmental Cell. 2003 ; Vol. 5, No. 5. pp. 695-707.
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