Recognition of the neural chemoattractant netrin-1 by integrins α6β4 and α3β1 regulates epithelial cell adhesion and migration

Mayra Yebra, Anthony M P Montgomery, Giuseppe R. Diaferia, Thomas Kaido, Steve Silletti, Brandon Perez, Margaret L. Just, Simone Hildbrand, Rosemary Hurford, Elin Florkiewicz, Marc Tessier-Lavigne, Vincenzo Cirulli

Research output: Contribution to journalArticlepeer-review

Abstract

Netrins, axon guidance cues in the CNS, have also been detected in epithelial tissues. In this study, using the embryonic pancreas as a model system, we show that Netrin-1 is expressed in a discrete population of epithelial cells, localizes to basal membranes, and specifically associates with elements of the extracellular matrix. We demonstrate that α6β4 integrin mediates pancreatic epithelial cell adhesion to Netrin-1, whereas recruitment of α6β4 and α3β1 regulate the migration of CK19+/PDX1+ putative pancreatic progenitors on Netrin-1. These results provide evidence for the activation of epithelial cell adhesion and migration by a neural chemoattractant, and identify Netrin-1/integrin interactions as adhesive/guidance cues for epithelial cells.

Original languageEnglish
Pages (from-to)695-707
Number of pages13
JournalDevelopmental Cell
Volume5
Issue number5
DOIs
Publication statusPublished - Nov 2003

ASJC Scopus subject areas

  • Developmental Biology

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