Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; Correlation with the induction of other cytokines

F. Ameglio, M. R. Capobianchi, C. Castilletti, P. C. Fei, S. Fais, E. Trento, F. Dianzani

Research output: Contribution to journalArticle

Abstract

Immunological abnormalities present in HIV-1-infected individuals often reflect an imbalance of cytokine production. The HIV-1 gp120 has the ability to induce a number of cytokines, and to enhance immunoglobulin release by normal peripheral blood mononuclear cells (PBMC) in vitro, in the absence of IL-2 production and of lymphoproliferation. This study provides evidence that gp120 is a potent IL-10 inducer in normal PBMC cultures. The pattern of other cytokines induced by gp120 includes interferon-alpha (IFN-α) and IFN-γ, tumour necrosis factor-alpha (TNF-α), IL-6, IL-1α and -β, and not IL-2 and IL-4. These findings further define the pattern of cytokine release induced by gp120 on human resting PBMC. Furthermore, the present findings roughly parallel those observed both in the sera of patients and in the mononuclear cells from HIV+ individuals early after infection, suggesting that gp120 could be a good candidate as one of the agents responsible for cytokine dysregulation observed in HIV-1-infected individuals.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalClinical and Experimental Immunology
Volume95
Issue number3
Publication statusPublished - 1994

Keywords

  • cytokines
  • HIV envelope glycoprotein
  • IL-10
  • immune dysregulation

ASJC Scopus subject areas

  • Immunology

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