Recombinant human erythropoietin may correct erythropoietin-deficient hyporegenerative anaemia in children given cardiac transplantation

F. Locatelli, M. Zecca, F. Mamprin, A. Gamba, G. Giorgiani, P. De Stefano

Research output: Contribution to journalArticle

Abstract

Cyclosporin-A reduces erythropoietin production and, together with the inhibitory effect of cytokines on erythropoiesis, may be potentially responsible for the anaemia observed in some patients after heart transplantation. Two children given cardiac transplantation and receiving cyclosporin-A developed transfusion-dependent hyporegenerative anaemia, Erythropoietin production was inappropriately low for the degree of anaemia, with an observed/predicted log(serum EPO) ratio of 0.54 and 0.49, respectively. The children were treated with rHuEPO at a dose of 75 U/kg three times weekly for 1 month and then twice weekly via subcutaneous injection. No further transfusion was necessary and restoration of normal erythroid activity was obtained, with normal haemoglobin values. No adverse effects were observed. Our experience suggests that recombinant human erythropoietin may be useful in treating the anaemia associated with cardiac transplantation.

Original languageEnglish
Pages (from-to)623-625
Number of pages3
JournalBritish Journal of Haematology
Volume88
Issue number3
Publication statusPublished - 1994

Keywords

  • Cardiac transplantation
  • Cyclosporine-A
  • Cytokines
  • Erythropoietin
  • Hyporegenerative anaemia

ASJC Scopus subject areas

  • Hematology

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