Recombinant human G-CSF-mobilized peripheral blood stem cells for second allogeneic transplant after bone marrow graft rejection in children

Marco Zecca, Cesare Perotti, Pierluigi Marradi, Daniela Montagna, Giovanna Giorgiani, Rita Balter, Luisella Prete, Franco Locatelli

Research output: Contribution to journalArticlepeer-review

Abstract

Two children affected by severe aplastic anaemia and sickle cell anaemia rejected the allogeneic bone marrow transplantation from an HLA-matched unrelated volunteer and an HLA-identical sibling, respectively. In both cases a second transplant using granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSC) was performed. Donors were the HLA-haploidentical mother and the same HLA-identical sibling who was employed for the first marrow allograft, respectively. Treatment with G-CSF and PBSC collection were well tolerated. Both patients had engraftment of donor haemopoiesis and did not experience severe graft-versus-host disease. These cases confirm that PBSC transplant should be considered as a feasible treatment to reverse graft failure in paediatric patients.

Original languageEnglish
Pages (from-to)432-434
Number of pages3
JournalBritish Journal of Haematology
Volume92
Issue number2
Publication statusPublished - 1996

Keywords

  • Allogeneic bone marrow transplantation
  • Graft rejection
  • Peripheral blood stem cells
  • Recombinant human granulocyte-colony stimulating factor

ASJC Scopus subject areas

  • Hematology

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