Abstract
OBJECTIVE: Some extra-thyroid actions of thyroid stimulating hormone (TSH), such as an in vitro action on bone, have been described. Our aim was to evaluate in vivo the acute effect of a recombinant human TSH (rhTSH)-induced TSH surge on Osteoprotegerin (OPG) and receptor activator of the nuclear factor-kappaBeta (RANK-L) levels in patients under levo-thyroxine (L-T4) therapy. DESIGN: 24 patients with differentiated thyroid carcinoma (DTC) were studied. Standard rhTSH testing was performed. OPG, RANK-L, TSH, thyroid hormones, thyroglobulin and several parameters of bone metabolism were evaluated. RESULTS: Baseline OPG and RANK-L levels were in the range of our reference population. An inverse correlation between OPG and spinal Z-score (p=0.029) and between RANK-L and age (p=0.018) or urinary calcium/creatinine ratio (p=0.011) was detected. After rhTSH administration, a significant (p
| Original language | English |
|---|---|
| Pages (from-to) | 304-313 |
| Number of pages | 10 |
| Journal | Hormones |
| Volume | 6 |
| Issue number | 4 |
| Publication status | Published - Oct 2007 |
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Recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-kappaBeta ligand in patients under evaluation for differentiated thyroid carcinoma. / Giusti, Massimo; Cecoli, Francesca; Ghiara, Carla; Rubinacci, Alessandro; Villa, Isabella; Cavallero, Domenico; Mazzuoli, Laura; Mussap, Michele; Lanzi, Roberto; Minuto, Francesco.
In: Hormones, Vol. 6, No. 4, 10.2007, p. 304-313.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-kappaBeta ligand in patients under evaluation for differentiated thyroid carcinoma.
AU - Giusti, Massimo
AU - Cecoli, Francesca
AU - Ghiara, Carla
AU - Rubinacci, Alessandro
AU - Villa, Isabella
AU - Cavallero, Domenico
AU - Mazzuoli, Laura
AU - Mussap, Michele
AU - Lanzi, Roberto
AU - Minuto, Francesco
PY - 2007/10
Y1 - 2007/10
N2 - OBJECTIVE: Some extra-thyroid actions of thyroid stimulating hormone (TSH), such as an in vitro action on bone, have been described. Our aim was to evaluate in vivo the acute effect of a recombinant human TSH (rhTSH)-induced TSH surge on Osteoprotegerin (OPG) and receptor activator of the nuclear factor-kappaBeta (RANK-L) levels in patients under levo-thyroxine (L-T4) therapy. DESIGN: 24 patients with differentiated thyroid carcinoma (DTC) were studied. Standard rhTSH testing was performed. OPG, RANK-L, TSH, thyroid hormones, thyroglobulin and several parameters of bone metabolism were evaluated. RESULTS: Baseline OPG and RANK-L levels were in the range of our reference population. An inverse correlation between OPG and spinal Z-score (p=0.029) and between RANK-L and age (p=0.018) or urinary calcium/creatinine ratio (p=0.011) was detected. After rhTSH administration, a significant (p
AB - OBJECTIVE: Some extra-thyroid actions of thyroid stimulating hormone (TSH), such as an in vitro action on bone, have been described. Our aim was to evaluate in vivo the acute effect of a recombinant human TSH (rhTSH)-induced TSH surge on Osteoprotegerin (OPG) and receptor activator of the nuclear factor-kappaBeta (RANK-L) levels in patients under levo-thyroxine (L-T4) therapy. DESIGN: 24 patients with differentiated thyroid carcinoma (DTC) were studied. Standard rhTSH testing was performed. OPG, RANK-L, TSH, thyroid hormones, thyroglobulin and several parameters of bone metabolism were evaluated. RESULTS: Baseline OPG and RANK-L levels were in the range of our reference population. An inverse correlation between OPG and spinal Z-score (p=0.029) and between RANK-L and age (p=0.018) or urinary calcium/creatinine ratio (p=0.011) was detected. After rhTSH administration, a significant (p
UR - http://www.scopus.com/inward/record.url?scp=38849188023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38849188023&partnerID=8YFLogxK
M3 - Article
C2 - 18055421
AN - SCOPUS:38849188023
VL - 6
SP - 304
EP - 313
JO - Hormones
JF - Hormones
SN - 1109-3099
IS - 4
ER -