Recombinant interferon-α2b affects proliferation, steroid receptors and sensitivity to tamoxifen of cultured breast cancer cells (CG-5)

G. Sica, F. Iacopino, G. Robustelli Della Cuna, P. Marchetti

Research output: Contribution to journalArticlepeer-review

Abstract

Exposure of CG-5 human breast cancer cells to recombinant interferon (IFN)-α2b results in a significant inhibition of cell proliferation; this is observed when cells are cultured in their standard conditions and is not modified if serum concentration present in the culture medium is lowered. Estrogen receptors are increased in CG-5 cells following a 5 day treatment with concentrations of IFN-α2b ranging from 10 to 1000 IU/ml of culture medium. Progesterone receptors seem to be more influenced by a longer treatment with the drug (7 days). The K(d) of both receptors is not modified by the exposure of cells to IFN-α2b. Finally, the antiproliferative effect of tamoxifen on CG-5 cells is amplified by the simultaneous addition to culture medium of IFN-α2b even at very low concentrations.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalAnti-Cancer Drugs
Volume3
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology

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