Recombinant interferon-α2b improves immune response to hepatitis B vaccination in haemodialysis patients: Results of a randomised clinical trial

María E. Miquilena-Colina, Tamara Lozano-Rodríguez, Leonor García-Pozo, Alicia Sáez, Paola Rizza, Imerio Capone, Maria Rapicetta, Paola Chionne, Maria Capobianchi, Marina Selleri, Concetta Castilletti, Filippo Belardelli, Oreste L. Iacono, Carmelo García-Monzón

Research output: Contribution to journalArticlepeer-review

Abstract

The use of adjuvants capable of improving the deficient immune response to hepatitis B virus (HBV) vaccine in haemodialysis patients is highly needed. Among potential adjuvants, type I interferons deserve a special attention in view of their known effects promoting cellular and humoral immune responses. The aim of the present trial was to evaluate the effects of recombinant interferon-α2b (IFN) administered as an adjuvant of HBV vaccine in unvaccinated haemodialysis patients. A significant and early enhancing effect on the antibody response was observed in patients receiving IFN. In addition, a predominance of IgG1 anti-HBs along with a transient normalization of circulating Th1 lymphocytes was only found in patients receiving IFN who achieved an early seroprotection. However, 6 months after the last vaccine dose, no significant differences were observed in the seroprotection rate achieved in patients vaccinated with IFN compared to that in patients receiving HBV vaccine alone. Mild to moderate fever, asthenia, and arthromyalgia were the most common reactions that occurred in vaccinees given IFN. In conclusion, addition of IFN to HBV vaccine, under the conditions used in this trial, is safe and achieves an earlier and higher seroprotection rate improving Th1-dependent immune response in haemodialysis patients.

Original languageEnglish
Pages (from-to)5654-5660
Number of pages7
JournalVaccine
Volume27
Issue number41
DOIs
Publication statusPublished - Sep 18 2009

Keywords

  • Adjuvant
  • Hepatitis B vaccine
  • Interferon-α

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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