Recombinant LH administration in subsequent cycle after "unexpected" poor response to recombinant FSH monotherapy.

Enrico Papaleo, Valeria Stella Vanni, Paola Viganò, Antonio La Marca, Luca Pagliardini, Rossella Vitrano, Mara Zanirato, Elena Marsiglio, Laura Privitera, Massimo Candiani

Research output: Contribution to journalArticlepeer-review


Poor ovarian response (POR) is most frequently linked to the condition known as diminished ovarian reserve, but it can also occur in the absence of pathological ovarian reserve tests ("unexpected" POR). Because possible explanations include theca cells function deficiency, our aim was to evaluate the effect of r-LH administration in "unexpected" poor responders. A retrospective, single-centre, cohort study was conducted on 65 patients with AMH >0.5ng/ml and/or AFC >5 with POR in their first cycle. Patients underwent a second IVF cycle with same protocol (long- or antagonist) and same starting dose of r-FSH used in the first cycle, plus daily addiction of 150IU of r-LH from day 1. Compared to the first cycle, r-LH addition in the second cycle determined an increase in number of oocytes retrieved (p

Original languageEnglish
Pages (from-to)813-816
Number of pages4
JournalGynecological Endocrinology
Issue number11
Publication statusPublished - Nov 1 2014


  • Controlled ovarian stimulation
  • Poor ovarian response
  • Recombinant LH
  • Theca cells

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Obstetrics and Gynaecology
  • Medicine(all)

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