Mutations in recombination activating genes cause a spectrum of severe immunodeficiencies ranging from T-B severe combined immunodeficiency to Omenn syndrome (a particular type of severe combined immunodeficiency presenting a T+ B- profile). Although environmental factors and genetic background could also contribute to the genesis of this pathological condition, a residual recombination activating gene activity allowing for a few recombinational events to occur, is the first determinant of this variability in the clinical picture.
|Number of pages||5|
|Journal||Current Opinion in Allergy and Clinical Immunology|
|Publication status||Published - Dec 2001|
ASJC Scopus subject areas
- Immunology and Allergy