Recommendations Concerning the First-Line Treatment of Children with Tuberculosis

Nicola Principi, Luisa Galli, Laura Lancella, Marina Tadolini, Giovanni Battista Migliori, Alberto Villani, Susanna Esposito, The Italian Pediatric Tb Study Group For The Italian Pediatric Tb Study Group

Research output: Contribution to journalArticle

Abstract

This document describes the recommendations of a group of scientific societies concerning the first-line therapeutic approach to paediatric tuberculosis (TB). The treatment of pulmonary TB should be based on the existence of parenchymal involvement and the risk of antibiotic resistance. The treatment of extra-pulmonary TB is based on the regimens used for severe pulmonary TB. The administration of corticosteroids is recommended only in cases of miliary TB, tuberculous meningitis and tuberculous pericarditis. Vitamin B6 may be indicated in the case of isoniazid-treated TB in breastfeeding infants, severely malnourished subjects, or patients with other diseases at high risk of vitamin deficiency. Once having started treatment, children with TB should be carefully followed up in order to evaluate compliance, the response to treatment, the need for treatment changes, and the presence of drug-related adverse events. Primary care paediatricians can support reference centres in providing family healthcare education and encouraging treatment compliance.

Original languageEnglish
Pages (from-to)13-23
Number of pages11
JournalPediatric Drugs
Volume18
Issue number1
DOIs
Publication statusPublished - 2016

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Tuberculosis
Pulmonary Tuberculosis
Meningeal Tuberculosis
Therapeutics
Tuberculous Pericarditis
Miliary Tuberculosis
Avitaminosis
Vitamin B 6
Isoniazid
Microbial Drug Resistance
Breast Feeding
Drug-Related Side Effects and Adverse Reactions
Compliance
Primary Health Care
Adrenal Cortex Hormones
Pediatrics
Delivery of Health Care
Education

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pharmacology (medical)

Cite this

Principi, N., Galli, L., Lancella, L., Tadolini, M., Migliori, G. B., Villani, A., ... For The Italian Pediatric Tb Study Group, T. I. P. T. S. G. (2016). Recommendations Concerning the First-Line Treatment of Children with Tuberculosis. Pediatric Drugs, 18(1), 13-23. https://doi.org/10.1007/s40272-015-0155-z

Recommendations Concerning the First-Line Treatment of Children with Tuberculosis. / Principi, Nicola; Galli, Luisa; Lancella, Laura; Tadolini, Marina; Migliori, Giovanni Battista; Villani, Alberto; Esposito, Susanna; For The Italian Pediatric Tb Study Group, The Italian Pediatric Tb Study Group.

In: Pediatric Drugs, Vol. 18, No. 1, 2016, p. 13-23.

Research output: Contribution to journalArticle

Principi, N, Galli, L, Lancella, L, Tadolini, M, Migliori, GB, Villani, A, Esposito, S & For The Italian Pediatric Tb Study Group, TIPTSG 2016, 'Recommendations Concerning the First-Line Treatment of Children with Tuberculosis', Pediatric Drugs, vol. 18, no. 1, pp. 13-23. https://doi.org/10.1007/s40272-015-0155-z
Principi, Nicola ; Galli, Luisa ; Lancella, Laura ; Tadolini, Marina ; Migliori, Giovanni Battista ; Villani, Alberto ; Esposito, Susanna ; For The Italian Pediatric Tb Study Group, The Italian Pediatric Tb Study Group. / Recommendations Concerning the First-Line Treatment of Children with Tuberculosis. In: Pediatric Drugs. 2016 ; Vol. 18, No. 1. pp. 13-23.
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