Recommendations Concerning the First-Line Treatment of Children with Tuberculosis

Nicola Principi; Luisa Galli; Laura Lancella; Marina Tadolini; Giovanni Battista Migliori; Alberto Villani; Susanna Esposito; null For the Italian Pediatric TB Study Group; Samantha Bosis; Claudia Tagliabue; Laura Senatore; Beatrice Ascolese; Laura Cursi; Annalisa Grandin; Caterina Marabotto; Maurizio de Martino; Elena Chiappini; Carlotta Montagnani; Daniele Ciofi; Filippo Festini; Martina Anziati; Sabrina Becciani; Giulia Remaschi; Sara Sollai; Chiara Tersigni; Elisabetta Venturini; Alfredo Guarino; Andrea Lo Vecchio; Riccardo Scotto; Filippo Bernardi; Elisa Bertazzoni; Francesco Blasi; Marialuisa Bocchino; Luca Assante; Elio Castagnola; Giuseppe Losurdo; Luigi Codecasa; Giuseppe Di Mauro; Marino Faccini; Clara Gabiano; Silvia Garazzino; Daniele Le Serre; Irene Raffaldi; Gianluigi Marseglia; Amelia Mascolo; Amelia Di Comite; Mauro Stronati; Lia D'Ambrosio; Rosella Centis; Daniela Cirillo; Enrico Tortoli; Angela Pasinato; Cristina Russo; Franco Scaglione; Elisabetta Scala; Paolo Tomà; Alberto Matteelli

doi:10.1007/s40272-015-0155-z

Recommendations Concerning the First-Line Treatment of Children with Tuberculosis

Nicola Principi, Luisa Galli, Laura Lancella, Marina Tadolini, Giovanni Battista Migliori, Alberto Villani, Susanna Esposito, For the Italian Pediatric TB Study Group, Samantha Bosis, Claudia Tagliabue, Laura Senatore, Beatrice Ascolese, Laura Cursi, Annalisa Grandin, Caterina Marabotto, Maurizio de Martino, Elena Chiappini, Carlotta Montagnani, Daniele Ciofi, Filippo FestiniMartina Anziati, Sabrina Becciani, Giulia Remaschi, Sara Sollai, Chiara Tersigni, Elisabetta Venturini, Alfredo Guarino, Andrea Lo Vecchio, Riccardo Scotto, Filippo Bernardi, Elisa Bertazzoni, Francesco Blasi, Marialuisa Bocchino, Luca Assante, Elio Castagnola, Giuseppe Losurdo, Luigi Codecasa, Giuseppe Di Mauro, Marino Faccini, Clara Gabiano, Silvia Garazzino, Daniele Le Serre, Irene Raffaldi, Gianluigi Marseglia, Amelia Mascolo, Amelia Di Comite, Mauro Stronati, Lia D'Ambrosio, Rosella Centis, Daniela Cirillo, Enrico Tortoli, Angela Pasinato, Cristina Russo, Franco Scaglione, Elisabetta Scala, Paolo Tomà, Alberto Matteelli

Research output: Contribution to journal › Review article › peer-review

Abstract

This document describes the recommendations of a group of scientific societies concerning the first-line therapeutic approach to paediatric tuberculosis (TB). The treatment of pulmonary TB should be based on the existence of parenchymal involvement and the risk of antibiotic resistance. The treatment of extra-pulmonary TB is based on the regimens used for severe pulmonary TB. The administration of corticosteroids is recommended only in cases of miliary TB, tuberculous meningitis and tuberculous pericarditis. Vitamin B6 may be indicated in the case of isoniazid-treated TB in breastfeeding infants, severely malnourished subjects, or patients with other diseases at high risk of vitamin deficiency. Once having started treatment, children with TB should be carefully followed up in order to evaluate compliance, the response to treatment, the need for treatment changes, and the presence of drug-related adverse events. Primary care paediatricians can support reference centres in providing family healthcare education and encouraging treatment compliance.

Original language	English
Pages (from-to)	13 - 23
Number of pages	11
Journal	Pediatric Drugs
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/s40272-015-0155-z
Publication status	Published - Feb 1 2016

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pharmacology (medical)

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10.1007/s40272-015-0155-z

Cite this

Principi, N., Galli, L., Lancella, L., Tadolini, M., Migliori, G. B., Villani, A., Esposito, S., For the Italian Pediatric TB Study Group, Bosis, S., Tagliabue, C., Senatore, L., Ascolese, B., Cursi, L., Grandin, A., Marabotto, C., de Martino, M., Chiappini, E., Montagnani, C., Ciofi, D., ... Matteelli, A. (2016). Recommendations Concerning the First-Line Treatment of Children with Tuberculosis. Pediatric Drugs, 18(1), 13 - 23. https://doi.org/10.1007/s40272-015-0155-z

Recommendations Concerning the First-Line Treatment of Children with Tuberculosis. / Principi, Nicola; Galli, Luisa; Lancella, Laura; Tadolini, Marina; Migliori, Giovanni Battista ; Villani, Alberto; Esposito, Susanna; For the Italian Pediatric TB Study Group, ; Bosis, Samantha ; Tagliabue, Claudia; Senatore, Laura; Ascolese, Beatrice; Cursi, Laura; Grandin, Annalisa; Marabotto, Caterina; de Martino, Maurizio; Chiappini, Elena; Montagnani, Carlotta; Ciofi, Daniele; Festini, Filippo; Anziati, Martina; Becciani, Sabrina; Remaschi, Giulia; Sollai, Sara; Tersigni, Chiara; Venturini, Elisabetta; Guarino, Alfredo; Vecchio, Andrea Lo; Scotto, Riccardo; Bernardi, Filippo; Bertazzoni, Elisa; Blasi, Francesco; Bocchino, Marialuisa; Assante, Luca; Castagnola, Elio; Losurdo, Giuseppe; Codecasa, Luigi; Di Mauro, Giuseppe; Faccini, Marino; Gabiano, Clara; Garazzino, Silvia; Le Serre, Daniele; Raffaldi, Irene; Marseglia, Gianluigi; Mascolo, Amelia; Di Comite, Amelia; Stronati, Mauro; D'Ambrosio, Lia; Centis, Rosella ; Cirillo, Daniela; Tortoli, Enrico; Pasinato, Angela; Russo, Cristina; Scaglione, Franco; Scala, Elisabetta; Tomà, Paolo; Matteelli, Alberto.

In: Pediatric Drugs, Vol. 18, No. 1, 01.02.2016, p. 13 - 23.

Research output: Contribution to journal › Review article › peer-review

Principi, N, Galli, L, Lancella, L, Tadolini, M, Migliori, GB , Villani, A, Esposito, S, For the Italian Pediatric TB Study Group, , Bosis, S , Tagliabue, C, Senatore, L, Ascolese, B, Cursi, L, Grandin, A, Marabotto, C, de Martino, M, Chiappini, E, Montagnani, C, Ciofi, D, Festini, F, Anziati, M, Becciani, S, Remaschi, G, Sollai, S, Tersigni, C, Venturini, E, Guarino, A, Vecchio, AL, Scotto, R, Bernardi, F, Bertazzoni, E, Blasi, F, Bocchino, M, Assante, L, Castagnola, E, Losurdo, G, Codecasa, L, Di Mauro, G, Faccini, M, Gabiano, C, Garazzino, S, Le Serre, D, Raffaldi, I, Marseglia, G, Mascolo, A, Di Comite, A, Stronati, M, D'Ambrosio, L, Centis, R , Cirillo, D, Tortoli, E, Pasinato, A, Russo, C, Scaglione, F, Scala, E, Tomà, P & Matteelli, A 2016, 'Recommendations Concerning the First-Line Treatment of Children with Tuberculosis', Pediatric Drugs, vol. 18, no. 1, pp. 13 - 23. https://doi.org/10.1007/s40272-015-0155-z

Principi, Nicola ; Galli, Luisa ; Lancella, Laura ; Tadolini, Marina ; Migliori, Giovanni Battista ; Villani, Alberto ; Esposito, Susanna ; For the Italian Pediatric TB Study Group, ; Bosis, Samantha ; Tagliabue, Claudia ; Senatore, Laura ; Ascolese, Beatrice ; Cursi, Laura ; Grandin, Annalisa ; Marabotto, Caterina ; de Martino, Maurizio ; Chiappini, Elena ; Montagnani, Carlotta ; Ciofi, Daniele ; Festini, Filippo ; Anziati, Martina ; Becciani, Sabrina ; Remaschi, Giulia ; Sollai, Sara ; Tersigni, Chiara ; Venturini, Elisabetta ; Guarino, Alfredo ; Vecchio, Andrea Lo ; Scotto, Riccardo ; Bernardi, Filippo ; Bertazzoni, Elisa ; Blasi, Francesco ; Bocchino, Marialuisa ; Assante, Luca ; Castagnola, Elio ; Losurdo, Giuseppe ; Codecasa, Luigi ; Di Mauro, Giuseppe ; Faccini, Marino ; Gabiano, Clara ; Garazzino, Silvia ; Le Serre, Daniele ; Raffaldi, Irene ; Marseglia, Gianluigi ; Mascolo, Amelia ; Di Comite, Amelia ; Stronati, Mauro ; D'Ambrosio, Lia ; Centis, Rosella ; Cirillo, Daniela ; Tortoli, Enrico ; Pasinato, Angela ; Russo, Cristina ; Scaglione, Franco ; Scala, Elisabetta ; Tomà, Paolo ; Matteelli, Alberto. / Recommendations Concerning the First-Line Treatment of Children with Tuberculosis. In: Pediatric Drugs. 2016 ; Vol. 18, No. 1. pp. 13 - 23.

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abstract = "This document describes the recommendations of a group of scientific societies concerning the first-line therapeutic approach to paediatric tuberculosis (TB). The treatment of pulmonary TB should be based on the existence of parenchymal involvement and the risk of antibiotic resistance. The treatment of extra-pulmonary TB is based on the regimens used for severe pulmonary TB. The administration of corticosteroids is recommended only in cases of miliary TB, tuberculous meningitis and tuberculous pericarditis. Vitamin B6 may be indicated in the case of isoniazid-treated TB in breastfeeding infants, severely malnourished subjects, or patients with other diseases at high risk of vitamin deficiency. Once having started treatment, children with TB should be carefully followed up in order to evaluate compliance, the response to treatment, the need for treatment changes, and the presence of drug-related adverse events. Primary care paediatricians can support reference centres in providing family healthcare education and encouraging treatment compliance.",

author = "Nicola Principi and Luisa Galli and Laura Lancella and Marina Tadolini and Migliori, {Giovanni Battista} and Alberto Villani and Susanna Esposito and {For the Italian Pediatric TB Study Group} and Samantha Bosis and Claudia Tagliabue and Laura Senatore and Beatrice Ascolese and Laura Cursi and Annalisa Grandin and Caterina Marabotto and {de Martino}, Maurizio and Elena Chiappini and Carlotta Montagnani and Daniele Ciofi and Filippo Festini and Martina Anziati and Sabrina Becciani and Giulia Remaschi and Sara Sollai and Chiara Tersigni and Elisabetta Venturini and Alfredo Guarino and Vecchio, {Andrea Lo} and Riccardo Scotto and Filippo Bernardi and Elisa Bertazzoni and Francesco Blasi and Marialuisa Bocchino and Luca Assante and Elio Castagnola and Giuseppe Losurdo and Luigi Codecasa and {Di Mauro}, Giuseppe and Marino Faccini and Clara Gabiano and Silvia Garazzino and {Le Serre}, Daniele and Irene Raffaldi and Gianluigi Marseglia and Amelia Mascolo and {Di Comite}, Amelia and Mauro Stronati and Lia D'Ambrosio and Rosella Centis and Daniela Cirillo and Enrico Tortoli and Angela Pasinato and Cristina Russo and Franco Scaglione and Elisabetta Scala and Paolo Tom{\`a} and Alberto Matteelli",

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AU - Principi, Nicola

AU - Galli, Luisa

AU - Lancella, Laura

AU - Tadolini, Marina

AU - Migliori, Giovanni Battista

AU - Villani, Alberto

AU - Esposito, Susanna

AU - For the Italian Pediatric TB Study Group, null

AU - Bosis, Samantha

AU - Tagliabue, Claudia

AU - Senatore, Laura

AU - Ascolese, Beatrice

AU - Cursi, Laura

AU - Grandin, Annalisa

AU - Marabotto, Caterina

AU - de Martino, Maurizio

AU - Chiappini, Elena

AU - Montagnani, Carlotta

AU - Ciofi, Daniele

AU - Festini, Filippo

AU - Anziati, Martina

AU - Becciani, Sabrina

AU - Remaschi, Giulia

AU - Sollai, Sara

AU - Tersigni, Chiara

AU - Venturini, Elisabetta

AU - Guarino, Alfredo

AU - Vecchio, Andrea Lo

AU - Scotto, Riccardo

AU - Bernardi, Filippo

AU - Bertazzoni, Elisa

AU - Blasi, Francesco

AU - Bocchino, Marialuisa

AU - Assante, Luca

AU - Castagnola, Elio

AU - Losurdo, Giuseppe

AU - Codecasa, Luigi

AU - Di Mauro, Giuseppe

AU - Faccini, Marino

AU - Gabiano, Clara

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AU - Le Serre, Daniele

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AU - Marseglia, Gianluigi

AU - Mascolo, Amelia

AU - Di Comite, Amelia

AU - Stronati, Mauro

AU - D'Ambrosio, Lia

AU - Centis, Rosella

AU - Cirillo, Daniela

AU - Tortoli, Enrico

AU - Pasinato, Angela

AU - Russo, Cristina

AU - Scaglione, Franco

AU - Scala, Elisabetta

AU - Tomà, Paolo

AU - Matteelli, Alberto

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N2 - This document describes the recommendations of a group of scientific societies concerning the first-line therapeutic approach to paediatric tuberculosis (TB). The treatment of pulmonary TB should be based on the existence of parenchymal involvement and the risk of antibiotic resistance. The treatment of extra-pulmonary TB is based on the regimens used for severe pulmonary TB. The administration of corticosteroids is recommended only in cases of miliary TB, tuberculous meningitis and tuberculous pericarditis. Vitamin B6 may be indicated in the case of isoniazid-treated TB in breastfeeding infants, severely malnourished subjects, or patients with other diseases at high risk of vitamin deficiency. Once having started treatment, children with TB should be carefully followed up in order to evaluate compliance, the response to treatment, the need for treatment changes, and the presence of drug-related adverse events. Primary care paediatricians can support reference centres in providing family healthcare education and encouraging treatment compliance.

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JO - Paediatric Drugs

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SN - 1174-5878

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ER -

Recommendations Concerning the First-Line Treatment of Children with Tuberculosis

Abstract

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