TY - JOUR
T1 - Recommendations Concerning the First-Line Treatment of Children with Tuberculosis
AU - Principi, Nicola
AU - Galli, Luisa
AU - Lancella, Laura
AU - Tadolini, Marina
AU - Migliori, Giovanni Battista
AU - Villani, Alberto
AU - Esposito, Susanna
AU - For the Italian Pediatric TB Study Group, null
AU - Bosis, Samantha
AU - Tagliabue, Claudia
AU - Senatore, Laura
AU - Ascolese, Beatrice
AU - Cursi, Laura
AU - Grandin, Annalisa
AU - Marabotto, Caterina
AU - de Martino, Maurizio
AU - Chiappini, Elena
AU - Montagnani, Carlotta
AU - Ciofi, Daniele
AU - Festini, Filippo
AU - Anziati, Martina
AU - Becciani, Sabrina
AU - Remaschi, Giulia
AU - Sollai, Sara
AU - Tersigni, Chiara
AU - Venturini, Elisabetta
AU - Guarino, Alfredo
AU - Vecchio, Andrea Lo
AU - Scotto, Riccardo
AU - Bernardi, Filippo
AU - Bertazzoni, Elisa
AU - Blasi, Francesco
AU - Bocchino, Marialuisa
AU - Assante, Luca
AU - Castagnola, Elio
AU - Losurdo, Giuseppe
AU - Codecasa, Luigi
AU - Di Mauro, Giuseppe
AU - Faccini, Marino
AU - Gabiano, Clara
AU - Garazzino, Silvia
AU - Le Serre, Daniele
AU - Raffaldi, Irene
AU - Marseglia, Gianluigi
AU - Mascolo, Amelia
AU - Di Comite, Amelia
AU - Stronati, Mauro
AU - D'Ambrosio, Lia
AU - Centis, Rosella
AU - Cirillo, Daniela
AU - Tortoli, Enrico
AU - Pasinato, Angela
AU - Russo, Cristina
AU - Scaglione, Franco
AU - Scala, Elisabetta
AU - Tomà, Paolo
AU - Matteelli, Alberto
PY - 2016/2/1
Y1 - 2016/2/1
N2 - This document describes the recommendations of a group of scientific societies concerning the first-line therapeutic approach to paediatric tuberculosis (TB). The treatment of pulmonary TB should be based on the existence of parenchymal involvement and the risk of antibiotic resistance. The treatment of extra-pulmonary TB is based on the regimens used for severe pulmonary TB. The administration of corticosteroids is recommended only in cases of miliary TB, tuberculous meningitis and tuberculous pericarditis. Vitamin B6 may be indicated in the case of isoniazid-treated TB in breastfeeding infants, severely malnourished subjects, or patients with other diseases at high risk of vitamin deficiency. Once having started treatment, children with TB should be carefully followed up in order to evaluate compliance, the response to treatment, the need for treatment changes, and the presence of drug-related adverse events. Primary care paediatricians can support reference centres in providing family healthcare education and encouraging treatment compliance.
AB - This document describes the recommendations of a group of scientific societies concerning the first-line therapeutic approach to paediatric tuberculosis (TB). The treatment of pulmonary TB should be based on the existence of parenchymal involvement and the risk of antibiotic resistance. The treatment of extra-pulmonary TB is based on the regimens used for severe pulmonary TB. The administration of corticosteroids is recommended only in cases of miliary TB, tuberculous meningitis and tuberculous pericarditis. Vitamin B6 may be indicated in the case of isoniazid-treated TB in breastfeeding infants, severely malnourished subjects, or patients with other diseases at high risk of vitamin deficiency. Once having started treatment, children with TB should be carefully followed up in order to evaluate compliance, the response to treatment, the need for treatment changes, and the presence of drug-related adverse events. Primary care paediatricians can support reference centres in providing family healthcare education and encouraging treatment compliance.
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U2 - 10.1007/s40272-015-0155-z
DO - 10.1007/s40272-015-0155-z
M3 - Review article
VL - 18
SP - 13
EP - 23
JO - Paediatric Drugs
JF - Paediatric Drugs
SN - 1174-5878
IS - 1
ER -