Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe

G. Veronesi, D.R. Baldwin, C.I. Henschke, S. Ghislandi, S. Iavicoli, M. Oudkerk, H.J. De Koning, J. Shemesh, J.K. Field, J.J. Zulueta, D. Horgan, L.F. Navarrete, M.V. Infante, P. Novellis, R.L. Murray, N. Peled, C. Rampinelli, G. Rocco, R. Witold, G.V. ScagliottiM.C. Tammemagi, L. Bertolaccini, N. Triphuridet, R. Yip, A. Rossi, S. Senan, G. Ferrante, K. Brain, C. van der Aalst, L. Bonomo, D. Consonni, J.P. Van Meerbeeck, P. Maisonneuve, S. Novello, A. Devaraj, Z. Saghir, G. Pelosi

Research output: Contribution to journalArticlepeer-review

Abstract

Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39–61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)”—a large international group of physicians and other experts concerned with lung cancer—agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Original languageEnglish
Article number1672
Number of pages24
JournalCancers
Volume12
Issue number6
DOIs
Publication statusPublished - 2020

Keywords

  • Computed tomography
  • Consensus
  • Implementation
  • Low dose
  • Lung cancer
  • Mortality
  • Reduction
  • Screening
  • Statement
  • asbestos
  • Article
  • cancer risk
  • cancer screening
  • chronic obstructive lung disease
  • computer assisted tomography
  • coronary artery calcification
  • cost effectiveness analysis
  • demography
  • false positive result
  • health care cost
  • health care policy
  • health program
  • human
  • incidental finding
  • low dose computed tomography
  • lung cancer
  • lung emphysema
  • Netherlands
  • population research
  • practice guideline
  • prediction
  • quality adjusted life year
  • radiation dose
  • risk assessment
  • self report
  • smoking
  • smoking cessation
  • volumetry

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