Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte, Sven Brandau, Shu Hsia Chen, Mario P. Colombo, Alan B. Frey, Tim F. Greten, Susanna Mandruzzato, Peter J. Murray, Augusto Ochoa, Suzanne Ostrand-Rosenberg, Paulo C. Rodriguez, Antonio Sica, Viktor Umansky, Robert H. Vonderheide, Dmitry I. Gabrilovich

Research output: Contribution to journalReview article

Abstract

Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.

Original languageEnglish
Article number12150
JournalNature Communications
Volume7
DOIs
Publication statusPublished - Jul 6 2016

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suppressors
Terminology
recommendations
cells
Tumors
Communication
Research
confusion
regulators
Neoplasms
progressions
tumors
cancer
communication
Myeloid-Derived Suppressor Cells
retarding

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Bronte, V., Brandau, S., Chen, S. H., Colombo, M. P., Frey, A. B., Greten, T. F., ... Gabrilovich, D. I. (2016). Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nature Communications, 7, [12150]. https://doi.org/10.1038/ncomms12150

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. / Bronte, Vincenzo; Brandau, Sven; Chen, Shu Hsia; Colombo, Mario P.; Frey, Alan B.; Greten, Tim F.; Mandruzzato, Susanna; Murray, Peter J.; Ochoa, Augusto; Ostrand-Rosenberg, Suzanne; Rodriguez, Paulo C.; Sica, Antonio; Umansky, Viktor; Vonderheide, Robert H.; Gabrilovich, Dmitry I.

In: Nature Communications, Vol. 7, 12150, 06.07.2016.

Research output: Contribution to journalReview article

Bronte, V, Brandau, S, Chen, SH, Colombo, MP, Frey, AB, Greten, TF, Mandruzzato, S, Murray, PJ, Ochoa, A, Ostrand-Rosenberg, S, Rodriguez, PC, Sica, A, Umansky, V, Vonderheide, RH & Gabrilovich, DI 2016, 'Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards', Nature Communications, vol. 7, 12150. https://doi.org/10.1038/ncomms12150
Bronte, Vincenzo ; Brandau, Sven ; Chen, Shu Hsia ; Colombo, Mario P. ; Frey, Alan B. ; Greten, Tim F. ; Mandruzzato, Susanna ; Murray, Peter J. ; Ochoa, Augusto ; Ostrand-Rosenberg, Suzanne ; Rodriguez, Paulo C. ; Sica, Antonio ; Umansky, Viktor ; Vonderheide, Robert H. ; Gabrilovich, Dmitry I. / Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. In: Nature Communications. 2016 ; Vol. 7.
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