Abstract
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.
| Original language | English |
|---|---|
| Article number | 12150 |
| Journal | Nature Communications |
| Volume | 7 |
| DOIs | |
| Publication status | Published - Jul 6 2016 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Chemistry(all)
- Physics and Astronomy(all)
Cite this
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. / Bronte, Vincenzo; Brandau, Sven; Chen, Shu Hsia; Colombo, Mario P.; Frey, Alan B.; Greten, Tim F.; Mandruzzato, Susanna; Murray, Peter J.; Ochoa, Augusto; Ostrand-Rosenberg, Suzanne; Rodriguez, Paulo C.; Sica, Antonio; Umansky, Viktor; Vonderheide, Robert H.; Gabrilovich, Dmitry I.
In: Nature Communications, Vol. 7, 12150, 06.07.2016.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
AU - Bronte, Vincenzo
AU - Brandau, Sven
AU - Chen, Shu Hsia
AU - Colombo, Mario P.
AU - Frey, Alan B.
AU - Greten, Tim F.
AU - Mandruzzato, Susanna
AU - Murray, Peter J.
AU - Ochoa, Augusto
AU - Ostrand-Rosenberg, Suzanne
AU - Rodriguez, Paulo C.
AU - Sica, Antonio
AU - Umansky, Viktor
AU - Vonderheide, Robert H.
AU - Gabrilovich, Dmitry I.
PY - 2016/7/6
Y1 - 2016/7/6
N2 - Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.
AB - Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.
UR - http://www.scopus.com/inward/record.url?scp=84977632889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84977632889&partnerID=8YFLogxK
U2 - 10.1038/ncomms12150
DO - 10.1038/ncomms12150
M3 - Review article
AN - SCOPUS:84977632889
VL - 7
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 12150
ER -