Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia

Jorge J. Castillo, Ramon Garcia-Sanz, Evdoxia Hatjiharissi, Robert A. Kyle, Xavier Leleu, Mary McMaster, Giampaolo Merlini, Monique C. Minnema, Enrica Morra, Roger G. Owen, Stephanie Poulain, Marvin J. Stone, Constantine Tam, Marzia Varettoni, Meletios A. Dimopoulos, Steven P. Treon, Efstathios Kastritis

Research output: Contribution to journalArticlepeer-review

Abstract

The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM.

Original languageEnglish
Pages (from-to)77-86
Number of pages10
JournalBritish Journal of Haematology
Volume175
Issue number1
DOIs
Publication statusPublished - Oct 1 2016

Keywords

  • amyloidosis
  • anaemia
  • Bing-Neel syndrome
  • hyperviscosity
  • neuropathy
  • Waldenström macroglobulinaemia

ASJC Scopus subject areas

  • Hematology

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