TY - JOUR
T1 - Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia
T2 - A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia
AU - Castillo, Jorge J.
AU - Garcia-Sanz, Ramon
AU - Hatjiharissi, Evdoxia
AU - Kyle, Robert A.
AU - Leleu, Xavier
AU - McMaster, Mary
AU - Merlini, Giampaolo
AU - Minnema, Monique C.
AU - Morra, Enrica
AU - Owen, Roger G.
AU - Poulain, Stephanie
AU - Stone, Marvin J.
AU - Tam, Constantine
AU - Varettoni, Marzia
AU - Dimopoulos, Meletios A.
AU - Treon, Steven P.
AU - Kastritis, Efstathios
PY - 2016/10/1
Y1 - 2016/10/1
N2 - The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM.
AB - The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues. We provide recommendations for history-taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations, such as anaemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM.
KW - amyloidosis
KW - anaemia
KW - Bing-Neel syndrome
KW - hyperviscosity
KW - neuropathy
KW - Waldenström macroglobulinaemia
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U2 - 10.1111/bjh.14196
DO - 10.1111/bjh.14196
M3 - Article
C2 - 27378193
AN - SCOPUS:84988524992
VL - 175
SP - 77
EP - 86
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -