Recommendations for the diagnosis of pediatric tuberculosis

Elena Chiappini, A. L O Vecchio, Silvia Garazzino, Gianluigi Marseglia, F. Bernardi, Elio Castagnola, Paolo Tomà, Daniela Maria Cirillo, Cristina Russo, Clara Gabiano, D. Ciofi, Giuseppe Losurdo, M. Bocchino, Enrico Tortoli, Marina Tadolini, Alberto Villani, A. Guarino, Susanna Esposito

Research output: Contribution to journalArticle


Tuberculosis (TB) is still the world’s second most frequent cause of death due to infectious diseases after HIV infection, and this has aroused greater interest in identifying and managing exposed subjects, whether they are simply infected or have developed one of the clinical variants of the disease. Unfortunately, not even the latest laboratory techniques are always successful in identifying affected children because they are more likely to have negative cultures and tuberculin skin test results, equivocal chest X-ray findings, and atypical clinical manifestations than adults. Furthermore, they are at greater risk of progressing from infection to active disease, particularly if they are very young. Consequently, pediatricians have to use different diagnostic strategies that specifically address the needs of children. This document describes the recommendations of a group of scientific societies concerning the signs and symptoms suggesting pediatric TB, and the diagnostic approach towards children with suspected disease.

Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Issue number1
Publication statusPublished - Jan 1 2016

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Chiappini, E., Vecchio, A. L. O., Garazzino, S., Marseglia, G., Bernardi, F., Castagnola, E., Tomà, P., Cirillo, D. M., Russo, C., Gabiano, C., Ciofi, D., Losurdo, G., Bocchino, M., Tortoli, E., Tadolini, M., Villani, A., Guarino, A., & Esposito, S. (2016). Recommendations for the diagnosis of pediatric tuberculosis. European Journal of Clinical Microbiology and Infectious Diseases, 35(1), 1-18.