Indicazioni per la misura delle principali proteine sieriche

Translated title of the contribution: Recommendations for the measurement of the most important plasma proteins

Maria Stella Graziani, Anna Caldini, Umberto Basile, Alberto Dolci, Simona Ferraro, Ilaria Ferrarotti, Ilenia Infusino, Maria Teresa Muratore, Michele Mussap, Laura Obici, Paola Pezzati, Giuseppe Previtali, Dominika Szoke, Alessandro Terreni, Martina Zaninotto, Giampaolo Merlini

Research output: Contribution to journalArticlepeer-review


This document, prepared on behalf of the SIBioC Protein Working Group, reviews the existing evidence for recommending the measurement of the most important plasma proteins. For each protein, the related chapter includes: a) a brief introduction describing main biological characteristics, b) the presentation of the available evidence, based on retrieved meta-analyses, systematic reviews, and international and national guidelines, and c) recommendations for the test ordering. The scientific evidence was searched on electronic databases (Medline, Cochrane's database of systematic reviews) and on the websites of scientific societies. Recommendations were classified on the basis of the source of the retrieved evidence as follows: (+++) official National or International guidelines, (++) meta-analyses or systematic reviews, (±) expert opinions and/or clinical practice, and (-) none (not recommended). The following proteins were considered in the paper: albumin, α 1-antitripsin, α 1-acid glycoprotein, α 2-macroglobulin, haptoglobin, β 2- microglobulin, C-reactive protein (both as marker of inflammation and cardiovascular risk), ceruloplasmin, cystatin C, complement factors, rheumatoid factor, ferritin, immunoglobulins (IgA, IgG, IgM, IgD), free light chains, retinol binding protein, soluble transferrin receptor, serum amyloid A, transferrin, and transtyretin.

Translated title of the contributionRecommendations for the measurement of the most important plasma proteins
Original languageItalian
Pages (from-to)244-267
Number of pages24
JournalBiochimica Clinica
Issue number4
Publication statusPublished - Aug 2012

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medical Laboratory Technology


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