Recommendations of the Italian society for rheumatology for the use of biologic (TNF-α blocking) agents in treatment of psoriatic arthritis

Carlo Salvarani, Ignazio Olivieri, Nicolò Pipitone, Fabrizio Cantini, Antonio Marchesoni, Leonardo Punzi, Raffaele Scarpa, Marco Matucci-Cerinic

Research output: Contribution to journalArticle

Abstract

Aim: To propose recommendations for the use of biologic TNF-α blocking) agents in the treatment of psoriatic arthritis (PsA). Methods: We developed these recommendations by reviewing the evidence published in medical journals and in abstracts of the American College of Rheumatology (ACR) and of the European League against Rheumatism. A draft of the recommendations was circulated to a group of Italian Rheumatologists with a special interest in PsA and in therapy with biologic agents, and their suggestions were incorporated in the final version. Results: A consensus was achieved regarding the initiation and the monitoring of anti-TNF-α agents in PsA. More specifically, we propose that anti-TNF-α agents be considered in active PsA resistant to non-steroidal anti-inflammatory drugs, to at least two local steroid injections and at least 2 conventional disease-modifying anti-rheumatic agents (in cases of oligo/monoarthritis and/or enthesitis), and to at least two conventional disease-modifying anti-rheumatic agents (in patients with peripheral joints synovitis). Disease activity monitoring should be based on a variety of outcome measures including the ACR response criteria modified for use in PsA, the Bath ankylosing spondylitis disease activity index (BASDAI), and the Maastricht ankylosing spondylitis enthesis score (MASES). A favorable Expert opinion, based on evaluation of clinical symptoms and signs, of laboratory investigations (particularly acute phase reactants), and of imaging studies (whenever appropriate) should also be obtained. Conclusions: These recommendations may be used for guidance in deciding which patients with PsA should receive biologic therapy. Regular updates of these recommendations will be implemented on the basis of the results of new clinical studies and of data from post-marketing surveillance.

Original languageEnglish
Pages (from-to)70-78
Number of pages9
JournalClinical and Experimental Rheumatology
Volume24
Issue number1
Publication statusPublished - Jan 2006

Keywords

  • Italian society for rheumatology
  • Psoriatic arthritis
  • Recommendation
  • TNF-α blocking

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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    Salvarani, C., Olivieri, I., Pipitone, N., Cantini, F., Marchesoni, A., Punzi, L., Scarpa, R., & Matucci-Cerinic, M. (2006). Recommendations of the Italian society for rheumatology for the use of biologic (TNF-α blocking) agents in treatment of psoriatic arthritis. Clinical and Experimental Rheumatology, 24(1), 70-78.