Recommendations of the Italian Society of Rheumatology for the treatment of the primary large-vessel vasculitis with biological agents

Nicolò Pipitone, Ignazio Olivieri, C. Salvarani

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To provide recommendations on behalf of the Italian Society for Rheumatology for the off-label use of biologic agents in the treatment of large-vessel vasculitis. Methods: A panel of experts performed a literature search and selected the evidence relevant to the topic. The following five large-vessel vasculitides were considered: giant cell arteritis, Takayasu arteritis, primary angiitis of the central nervous system, Cogan's syndrome, and Adamantiades-Behçet's disease. Results: A consensus was achieved regarding the indication of biologic agents for the treatment of large-vessel vasculitis. Levels of evidence were assigned to the papers retrieved, and the strength of the recommendations was graded according to the levels of evidence. Conclusions: These recommendations may be used for guidance in deciding which patients with large-vessel vasculitis should receive biologic therapy. Further updates of these recommendations may be published on the basis of the results of new clinical studies and of data from post-marketing surveillance.

Original languageEnglish
JournalClinical and Experimental Rheumatology
Volume30
Issue numberSUPPL. 70
Publication statusPublished - 2012

Keywords

  • Biologic agents
  • Large-vessel vasculitis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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