Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis

H. Vrenken, M. Jenkinson, M. A. Horsfield, M. Battaglini, R. A. Van Schijndel, E. Rostrup, J. J G Geurts, E. Fisher, A. Zijdenbos, J. Ashburner, D. H. Miller, M. Filippi, F. Fazekas, M. Rovaris, A. Rovira, F. Barkhof, N. De Stefano

Research output: Contribution to journalArticle

Abstract

Focal lesions and brain atrophy are the most extensively studied aspects of multiple sclerosis (MS), but the image acquisition and analysis techniques used can be further improved, especially those for studying within-patient changes of lesion load and atrophy longitudinally. Improved accuracy and sensitivity will reduce the numbers of patients required to detect a given treatment effect in a trial, and ultimately, will allow reliable characterization of individual patients for personalized treatment. Based on open issues in the field of MS research, and the current state of the art in magnetic resonance image analysis methods for assessing brain lesion load and atrophy, this paper makes recommendations to improve these measures for longitudinal studies of MS. Briefly, they are (1) images should be acquired using 3D pulse sequences, with near-isotropic spatial resolution and multiple image contrasts to allow more comprehensive analyses of lesion load and atrophy, across timepoints. Image artifacts need special attention given their effects on image analysis results. (2) Automated image segmentation methods integrating the assessment of lesion load and atrophy are desirable. (3) A standard dataset with benchmark results should be set up to facilitate development, calibration, and objective evaluation of image analysis methods for MS.

Original languageEnglish
Pages (from-to)2458-2471
Number of pages14
JournalJournal of Neurology
Volume260
Issue number10
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Neuroimaging
Multiple Sclerosis
Atrophy
Longitudinal Studies
Benchmarking
Brain
Artifacts
Calibration
Magnetic Resonance Spectroscopy
Therapeutics
Research

Keywords

  • Brain atrophy
  • Image analysis
  • Magnetic resonance imaging
  • Multiple sclerosis
  • White matter lesions

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Vrenken, H., Jenkinson, M., Horsfield, M. A., Battaglini, M., Van Schijndel, R. A., Rostrup, E., ... De Stefano, N. (2013). Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis. Journal of Neurology, 260(10), 2458-2471. https://doi.org/10.1007/s00415-012-6762-5

Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis. / Vrenken, H.; Jenkinson, M.; Horsfield, M. A.; Battaglini, M.; Van Schijndel, R. A.; Rostrup, E.; Geurts, J. J G; Fisher, E.; Zijdenbos, A.; Ashburner, J.; Miller, D. H.; Filippi, M.; Fazekas, F.; Rovaris, M.; Rovira, A.; Barkhof, F.; De Stefano, N.

In: Journal of Neurology, Vol. 260, No. 10, 10.2013, p. 2458-2471.

Research output: Contribution to journalArticle

Vrenken, H, Jenkinson, M, Horsfield, MA, Battaglini, M, Van Schijndel, RA, Rostrup, E, Geurts, JJG, Fisher, E, Zijdenbos, A, Ashburner, J, Miller, DH, Filippi, M, Fazekas, F, Rovaris, M, Rovira, A, Barkhof, F & De Stefano, N 2013, 'Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis', Journal of Neurology, vol. 260, no. 10, pp. 2458-2471. https://doi.org/10.1007/s00415-012-6762-5
Vrenken, H. ; Jenkinson, M. ; Horsfield, M. A. ; Battaglini, M. ; Van Schijndel, R. A. ; Rostrup, E. ; Geurts, J. J G ; Fisher, E. ; Zijdenbos, A. ; Ashburner, J. ; Miller, D. H. ; Filippi, M. ; Fazekas, F. ; Rovaris, M. ; Rovira, A. ; Barkhof, F. ; De Stefano, N. / Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis. In: Journal of Neurology. 2013 ; Vol. 260, No. 10. pp. 2458-2471.
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