Reconfiguration of DNA methylation in aging

Michele Zampieri, Fabio Ciccarone, Roberta Calabrese, Claudio Franceschi, Alexander Bürkle, Paola Caiafa

Research output: Contribution to journalArticlepeer-review


A complex interplay between multiple biological effects shapes the aging process. The advent of genome-wide quantitative approaches in the epigenetic field has highlighted the effective impact of epigenetic deregulation, particularly of DNA methylation, on aging. Age-associated alterations in DNA methylation are commonly grouped in the phenomenon known as "epigenetic drift" which is characterized by gradual extensive demethylation of genome and hypermethylation of a number of promoter-associated CpG islands. Surprisingly, specific DNA regions show directional epigenetic changes in aged individuals suggesting the importance of these events for the aging process. However, the epigenetic information obtained until now in aging needs a re-consideration due to the recent discovery of 5-hydroxymethylcytosine, a new DNA epigenetic mark present on genome. A recapitulation of the factors involved in the regulation of DNA methylation and the changes occurring in aging will be described in this review also considering the data available on 5hmC.

Original languageEnglish
Pages (from-to)60-70
Number of pages11
JournalMechanisms of Ageing and Development
Publication statusPublished - Nov 1 2015


  • 5-Hydroxymethylcytosine
  • 5-Methylcytosine
  • Aging
  • DNA methylation
  • Epigenetic reprogramming

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology


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