TY - JOUR
T1 - Reconfiguration of DNA methylation in aging
AU - Zampieri, Michele
AU - Ciccarone, Fabio
AU - Calabrese, Roberta
AU - Franceschi, Claudio
AU - Bürkle, Alexander
AU - Caiafa, Paola
PY - 2015/11/1
Y1 - 2015/11/1
N2 - A complex interplay between multiple biological effects shapes the aging process. The advent of genome-wide quantitative approaches in the epigenetic field has highlighted the effective impact of epigenetic deregulation, particularly of DNA methylation, on aging. Age-associated alterations in DNA methylation are commonly grouped in the phenomenon known as "epigenetic drift" which is characterized by gradual extensive demethylation of genome and hypermethylation of a number of promoter-associated CpG islands. Surprisingly, specific DNA regions show directional epigenetic changes in aged individuals suggesting the importance of these events for the aging process. However, the epigenetic information obtained until now in aging needs a re-consideration due to the recent discovery of 5-hydroxymethylcytosine, a new DNA epigenetic mark present on genome. A recapitulation of the factors involved in the regulation of DNA methylation and the changes occurring in aging will be described in this review also considering the data available on 5hmC.
AB - A complex interplay between multiple biological effects shapes the aging process. The advent of genome-wide quantitative approaches in the epigenetic field has highlighted the effective impact of epigenetic deregulation, particularly of DNA methylation, on aging. Age-associated alterations in DNA methylation are commonly grouped in the phenomenon known as "epigenetic drift" which is characterized by gradual extensive demethylation of genome and hypermethylation of a number of promoter-associated CpG islands. Surprisingly, specific DNA regions show directional epigenetic changes in aged individuals suggesting the importance of these events for the aging process. However, the epigenetic information obtained until now in aging needs a re-consideration due to the recent discovery of 5-hydroxymethylcytosine, a new DNA epigenetic mark present on genome. A recapitulation of the factors involved in the regulation of DNA methylation and the changes occurring in aging will be described in this review also considering the data available on 5hmC.
KW - 5-Hydroxymethylcytosine
KW - 5-Methylcytosine
KW - Aging
KW - DNA methylation
KW - Epigenetic reprogramming
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U2 - 10.1016/j.mad.2015.02.002
DO - 10.1016/j.mad.2015.02.002
M3 - Article
C2 - 25708826
AN - SCOPUS:84947028056
VL - 151
SP - 60
EP - 70
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
ER -