Reconstruction of cerebrospinal fluid flow in the third ventricle based on MRI data.

Vartan Kurtcuoglu, Michaela Soellinger, Paul Summers, Kevin Boomsma, Dimos Poulikakos, Peter Boesiger, Yiannis Ventikos

Research output: Chapter in Book/Report/Conference proceedingChapter


A finite-volume model of the cerebrospinal fluid (CSF) system encompassing the third ventricle and the aqueduct of Sylvius was used to reconstruct CSF velocity and pressure fields based on MRI data. The flow domain geometry was obtained through segmentation of MRI brain anatomy scans. The movement of the domain walls was interpolated from brain motion MRI scans. A constant pressure boundary condition (BC) was specified at the foramina of Monro. A transient velocity BC reconstructed from velocimetric MRI scans was employed at the inferior end of the aqueduct of Sylvius. It could be shown that a combination of MRI scans and computational fluid dynamics (CFD) simulation can be used to reconstruct the flow field in the third ventricle. Pre-interventional knowledge of patient-specific CSF flow has the potential to improve neurosurgical interventions such as shunt placement in case of hydrocephalus.

Original languageEnglish
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Number of pages8
EditionPt 1
Publication statusPublished - 2005


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