Reconstruction of the proximal femur with a modular resection prosthesis

Teresa Calabró, Rupert van Rooyen, Ilaria Piraino, Elisa Pala, Giulia Trovarelli, Georgios N. Panagopoulos, Panayiotis D. Megaloikonomos, Andrea Angelini, Andreas F. Mavrogenis, Pietro Ruggieri

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Various megaprostheses are currently available for reconstruction of the proximal femur after tumor resection. This study evaluates the survival and complications of a modular megaprosthesis for reconstruction of the proximal femur. Materials and methods: We studied the medical files of 109 tumor patients (age range 16–86 years) who underwent proximal femoral reconstruction with the MRP® megaprosthesis from 2002 to 2011. There were 70 patients with metastases, 34 patients with bone sarcomas, and five patients with hematological malignancies; 82 were primary and 27 were revision reconstructions. Mean follow-up was 2.5 years; 31 patients had a minimum five-year follow-up. We evaluated the survival and function of the patients, and the survival and complications of the megaprostheses. Results: Survival was significantly higher for the patients with bone sarcomas compared to those with metastases and hematological malignancies. Mean MSTS functional score was similar between patients with bone sarcomas and those with hematological malignancies and metastases, and between patients with primary and those with revision reconstructions. Overall survival of the MRP® megaprostheses was 74 % at 5 and 9 years. Fourteen (13.6 %) major complications occurred at a mean period of 1.4 years (range 3 months to 4.5 years); these included infection (5.8 %), dislocation (3.9 %), local recurrence (2.9 %), and acetabular fracture (1 %). Conclusion: MRP® megaprostheses are a valuable reconstruction option after tumor resection of the proximal femur.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalEuropean Journal of Orthopaedic Surgery and Traumatology
DOIs
Publication statusAccepted/In press - Apr 4 2016

Fingerprint

Femur
Prostheses and Implants
Hematologic Neoplasms
Survival
Sarcoma
Neoplasm Metastasis
Bone and Bones
Neoplasms
Thigh
Recurrence
Infection

Keywords

  • Limb salvage
  • Megaprosthetic reconstruction
  • MRP
  • Proximal femur

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Calabró, T., van Rooyen, R., Piraino, I., Pala, E., Trovarelli, G., Panagopoulos, G. N., ... Ruggieri, P. (Accepted/In press). Reconstruction of the proximal femur with a modular resection prosthesis. European Journal of Orthopaedic Surgery and Traumatology, 1-7. https://doi.org/10.1007/s00590-016-1764-0

Reconstruction of the proximal femur with a modular resection prosthesis. / Calabró, Teresa; van Rooyen, Rupert; Piraino, Ilaria; Pala, Elisa; Trovarelli, Giulia; Panagopoulos, Georgios N.; Megaloikonomos, Panayiotis D.; Angelini, Andrea; Mavrogenis, Andreas F.; Ruggieri, Pietro.

In: European Journal of Orthopaedic Surgery and Traumatology, 04.04.2016, p. 1-7.

Research output: Contribution to journalArticle

Calabró, T, van Rooyen, R, Piraino, I, Pala, E, Trovarelli, G, Panagopoulos, GN, Megaloikonomos, PD, Angelini, A, Mavrogenis, AF & Ruggieri, P 2016, 'Reconstruction of the proximal femur with a modular resection prosthesis', European Journal of Orthopaedic Surgery and Traumatology, pp. 1-7. https://doi.org/10.1007/s00590-016-1764-0
Calabró, Teresa ; van Rooyen, Rupert ; Piraino, Ilaria ; Pala, Elisa ; Trovarelli, Giulia ; Panagopoulos, Georgios N. ; Megaloikonomos, Panayiotis D. ; Angelini, Andrea ; Mavrogenis, Andreas F. ; Ruggieri, Pietro. / Reconstruction of the proximal femur with a modular resection prosthesis. In: European Journal of Orthopaedic Surgery and Traumatology. 2016 ; pp. 1-7.
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abstract = "Background: Various megaprostheses are currently available for reconstruction of the proximal femur after tumor resection. This study evaluates the survival and complications of a modular megaprosthesis for reconstruction of the proximal femur. Materials and methods: We studied the medical files of 109 tumor patients (age range 16–86 years) who underwent proximal femoral reconstruction with the MRP{\circledR} megaprosthesis from 2002 to 2011. There were 70 patients with metastases, 34 patients with bone sarcomas, and five patients with hematological malignancies; 82 were primary and 27 were revision reconstructions. Mean follow-up was 2.5 years; 31 patients had a minimum five-year follow-up. We evaluated the survival and function of the patients, and the survival and complications of the megaprostheses. Results: Survival was significantly higher for the patients with bone sarcomas compared to those with metastases and hematological malignancies. Mean MSTS functional score was similar between patients with bone sarcomas and those with hematological malignancies and metastases, and between patients with primary and those with revision reconstructions. Overall survival of the MRP{\circledR} megaprostheses was 74 {\%} at 5 and 9 years. Fourteen (13.6 {\%}) major complications occurred at a mean period of 1.4 years (range 3 months to 4.5 years); these included infection (5.8 {\%}), dislocation (3.9 {\%}), local recurrence (2.9 {\%}), and acetabular fracture (1 {\%}). Conclusion: MRP{\circledR} megaprostheses are a valuable reconstruction option after tumor resection of the proximal femur.",
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AU - Panagopoulos, Georgios N.

AU - Megaloikonomos, Panayiotis D.

AU - Angelini, Andrea

AU - Mavrogenis, Andreas F.

AU - Ruggieri, Pietro

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AB - Background: Various megaprostheses are currently available for reconstruction of the proximal femur after tumor resection. This study evaluates the survival and complications of a modular megaprosthesis for reconstruction of the proximal femur. Materials and methods: We studied the medical files of 109 tumor patients (age range 16–86 years) who underwent proximal femoral reconstruction with the MRP® megaprosthesis from 2002 to 2011. There were 70 patients with metastases, 34 patients with bone sarcomas, and five patients with hematological malignancies; 82 were primary and 27 were revision reconstructions. Mean follow-up was 2.5 years; 31 patients had a minimum five-year follow-up. We evaluated the survival and function of the patients, and the survival and complications of the megaprostheses. Results: Survival was significantly higher for the patients with bone sarcomas compared to those with metastases and hematological malignancies. Mean MSTS functional score was similar between patients with bone sarcomas and those with hematological malignancies and metastases, and between patients with primary and those with revision reconstructions. Overall survival of the MRP® megaprostheses was 74 % at 5 and 9 years. Fourteen (13.6 %) major complications occurred at a mean period of 1.4 years (range 3 months to 4.5 years); these included infection (5.8 %), dislocation (3.9 %), local recurrence (2.9 %), and acetabular fracture (1 %). Conclusion: MRP® megaprostheses are a valuable reconstruction option after tumor resection of the proximal femur.

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