Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy

A. Caraceni, C. Martini, G. Spatti, A. Thomas, M. Onofrj

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Introduction - We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cisplatin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. Methods - Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up. Results -Optic neuritis appeared 13 weeks after cisplatin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. Conclusion - Cisplatin can induce delayed optic neuritis, that can recover in 1 year.

Original languageEnglish
Pages (from-to)260-261
Number of pages2
JournalActa Neurologica Scandinavica
Issue number4
Publication statusPublished - 1997


  • Carboplatin
  • Cisplatin
  • Neurotoxicity
  • Optic neuropathy
  • Ovarian cancer

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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