Abstract
Introduction - We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cisplatin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. Methods - Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up. Results -Optic neuritis appeared 13 weeks after cisplatin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. Conclusion - Cisplatin can induce delayed optic neuritis, that can recover in 1 year.
| Original language | English |
|---|---|
| Pages (from-to) | 260-261 |
| Number of pages | 2 |
| Journal | Acta Neurologica Scandinavica |
| Volume | 96 |
| Issue number | 4 |
| Publication status | Published - 1997 |
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Keywords
- Carboplatin
- Cisplatin
- Neurotoxicity
- Optic neuropathy
- Ovarian cancer
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy. / Caraceni, A.; Martini, C.; Spatti, G.; Thomas, A.; Onofrj, M.
In: Acta Neurologica Scandinavica, Vol. 96, No. 4, 1997, p. 260-261.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy
AU - Caraceni, A.
AU - Martini, C.
AU - Spatti, G.
AU - Thomas, A.
AU - Onofrj, M.
PY - 1997
Y1 - 1997
N2 - Introduction - We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cisplatin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. Methods - Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up. Results -Optic neuritis appeared 13 weeks after cisplatin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. Conclusion - Cisplatin can induce delayed optic neuritis, that can recover in 1 year.
AB - Introduction - We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cisplatin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. Methods - Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up. Results -Optic neuritis appeared 13 weeks after cisplatin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. Conclusion - Cisplatin can induce delayed optic neuritis, that can recover in 1 year.
KW - Carboplatin
KW - Cisplatin
KW - Neurotoxicity
KW - Optic neuropathy
KW - Ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=0030825117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030825117&partnerID=8YFLogxK
M3 - Article
C2 - 9325480
AN - SCOPUS:0030825117
VL - 96
SP - 260
EP - 261
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
SN - 0001-6314
IS - 4
ER -