Abstract
Introduction - We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cisplatin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. Methods - Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up. Results -Optic neuritis appeared 13 weeks after cisplatin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. Conclusion - Cisplatin can induce delayed optic neuritis, that can recover in 1 year.
Original language | English |
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Pages (from-to) | 260-261 |
Number of pages | 2 |
Journal | Acta Neurologica Scandinavica |
Volume | 96 |
Issue number | 4 |
Publication status | Published - 1997 |
Keywords
- Carboplatin
- Cisplatin
- Neurotoxicity
- Optic neuropathy
- Ovarian cancer
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)