Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy

A. Caraceni, C. Martini, G. Spatti, A. Thomas, M. Onofrj

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Introduction - We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cisplatin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. Methods - Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up. Results -Optic neuritis appeared 13 weeks after cisplatin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. Conclusion - Cisplatin can induce delayed optic neuritis, that can recover in 1 year.

Original languageEnglish
Pages (from-to)260-261
Number of pages2
JournalActa Neurologica Scandinavica
Volume96
Issue number4
Publication statusPublished - 1997

Fingerprint

Optic Neuritis
Carboplatin
Cisplatin
Drug Therapy
Visual Evoked Potentials
Scotoma
Optic Nerve Diseases
Optic Nerve
Visual Fields
Carcinoma

Keywords

  • Carboplatin
  • Cisplatin
  • Neurotoxicity
  • Optic neuropathy
  • Ovarian cancer

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy. / Caraceni, A.; Martini, C.; Spatti, G.; Thomas, A.; Onofrj, M.

In: Acta Neurologica Scandinavica, Vol. 96, No. 4, 1997, p. 260-261.

Research output: Contribution to journalArticle

Caraceni, A, Martini, C, Spatti, G, Thomas, A & Onofrj, M 1997, 'Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy', Acta Neurologica Scandinavica, vol. 96, no. 4, pp. 260-261.
Caraceni, A. ; Martini, C. ; Spatti, G. ; Thomas, A. ; Onofrj, M. / Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy. In: Acta Neurologica Scandinavica. 1997 ; Vol. 96, No. 4. pp. 260-261.
@article{09ea08e0ae8a4703844136e13d5dbe45,
title = "Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy",
abstract = "Introduction - We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cisplatin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. Methods - Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up. Results -Optic neuritis appeared 13 weeks after cisplatin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. Conclusion - Cisplatin can induce delayed optic neuritis, that can recover in 1 year.",
keywords = "Carboplatin, Cisplatin, Neurotoxicity, Optic neuropathy, Ovarian cancer",
author = "A. Caraceni and C. Martini and G. Spatti and A. Thomas and M. Onofrj",
year = "1997",
language = "English",
volume = "96",
pages = "260--261",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley Blackwell",
number = "4",

}

TY - JOUR

T1 - Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy

AU - Caraceni, A.

AU - Martini, C.

AU - Spatti, G.

AU - Thomas, A.

AU - Onofrj, M.

PY - 1997

Y1 - 1997

N2 - Introduction - We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cisplatin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. Methods - Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up. Results -Optic neuritis appeared 13 weeks after cisplatin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. Conclusion - Cisplatin can induce delayed optic neuritis, that can recover in 1 year.

AB - Introduction - We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cisplatin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. Methods - Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up. Results -Optic neuritis appeared 13 weeks after cisplatin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. Conclusion - Cisplatin can induce delayed optic neuritis, that can recover in 1 year.

KW - Carboplatin

KW - Cisplatin

KW - Neurotoxicity

KW - Optic neuropathy

KW - Ovarian cancer

UR - http://www.scopus.com/inward/record.url?scp=0030825117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030825117&partnerID=8YFLogxK

M3 - Article

C2 - 9325480

AN - SCOPUS:0030825117

VL - 96

SP - 260

EP - 261

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 4

ER -