Recovery of gastric function after Helicobacter pylori eradication in subjects with body atrophic gastritis: Prospective 4-year study

Francesco Di Mario, Ali M. Moussa, Nadia Dal Bò, Pietro Caruana, Alberto Pilotto, Lucas G. Cavallaro, Giulia M. Cavestro, Veronica Iori, Roberta Merli, Angelo Franzé, Massimo Rugge

Research output: Contribution to journalArticlepeer-review


Background: The relationship between Helicobacter pylori (H. pylori) eradication and atrophic changes in the gastric mucosa has not yet been fully defined. Although studies report a partial restoration of serum pepsinogen I (sPGI) levels after eradication, it is not clear if this finding reflects gastric mucosal healing on a morphological level. Aim: To assess alterations in gastric function after H. pylori eradication on moderate/severe body atrophic gastritis by determination of sPGI levels. Methods: Twenty-three dyspeptic patients, selected from 284 consecutive H. pylori positive patients, with histological features of moderate/severe body atrophic gastritis and sPGI <25 μg/L (11 men, mean age: 51.8 years, range: 29-79 years), underwent an upper gastrointestinal endoscopy with gastric biopsies and sPGI determination at baseline. All patients underwent eradication therapy. Serum pepsinogen I was measured again after 6 months, and at 1, 2, 3 and 4 years after eradication therapy. Results: Mean sPGI levels prior to eradication were 11.9 μg/L (range: 4-23 μg/L). Six months after eradication therapy, mean sPGI levels significantly increased to 17.4 μg/L (P = 0.04). At the completion of the study, 4 years after eradication, sPGI levels increased from 17.4 to 32.7 μg/L (P = 0.01). A significant progressive increase in sPGI levels was observed from 6 months to 1 year (17.4 to 23.9 μg/L) and from 1 to 2 years (23.9 to 26.0 μg/L, P = 0.01). Serum pepsinogen I levels higher than the cut-off value of 25 μg/L were observed at various time-points: 6.3% of patients at 6 months (1/16), 33.3% (5/15) at 1 year, 50% (7/14) at 24 months, 66.7% (6/9) at 36 months and 87.5% (7/8) at 4 years. Conclusion: After H. pylori eradication, subjects with body atrophic gastritis showed long-term improvement of physiological gastric function, reflected by significantly and continually increasing sPGI levels over a 4-year period.

Original languageEnglish
Pages (from-to)1661-1666
Number of pages6
JournalJournal of Gastroenterology and Hepatology
Issue number11
Publication statusPublished - 2005


  • Eradication therapy
  • Helicobacter pylori related-atrophic body gastritis
  • Serum pepsinogen I

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology


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