Recovery of hand function with robot-assisted therapy in acute stroke patients: A randomized-controlled trial

Patrizio Sale, Stefano Mazzoleni, Valentina Lombardi, Daniele Galafate, Maria P. Massimiani, Federico Posteraro, Carlo Damiani, Marco Franceschini

Research output: Contribution to journalArticlepeer-review


In the last few years, not many studies on the use of robot-assisted therapy to recover hand function in acute stroke patients have been carried out. This randomized-controlled observer trial is aimed at evaluating the effects of intensive robot-assisted hand therapy compared with intensive occupational therapy in the early recovery phases after stroke with a 3-month follow-up. Twenty acute stroke patients at their first-ever stroke were enrolled and randomized into two groups. The experimental treatment was performed using the Amadeo Robotic System. Control treatment, instead, was carried out using occupational therapy executed by a trained physiotherapist. All participants received 20 sessions of treatment for 4 consecutive weeks (5 days/week). The following clinical scales, Fugl-Meyer Scale (FM), Medical Research Council Scale for Muscle Strength (hand flexor and extensor muscles) (MRC), Motricity Index (MI) and modified Ashworth Scale for wrist and hand muscles (MAS), were performed at baseline (T0), after 20 sessions (end of treatment) (T1) and at the 3-month follow-up (T2). The Barthel Index was assessed only at T0 and T1. Evidence of a significant improvement was shown by the Friedman test for the FM [experimental group (EG): P=0.0039, control group (CG): P

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalInternational Journal of Rehabilitation Research
Issue number3
Publication statusPublished - 2014


  • hand function
  • randomized-controlled trial
  • rehabilitation
  • robotic
  • stroke

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Medicine(all)


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