Abstract
Purpose: This study was aimed at assessing prospectively the effect of postoperative intracavernous injections of alprostadil on the recovery of spontaneous erectile function after nervesparing radical retropubic prostatectomy. Materials and Methods: A total of 30 potent patients with clinically localized prostate cancer (clinical stage B1 or B2, Gleason sum 7 or greater, prostatic specific antigen less than 20 ng./ml.) underwent nerve- sparing radical retropubic prostatectomy and was subsequently randomized to alprostadil injections 3 times per week for 12 weeks (group 1, 15 patients) or observation without any erectogenic treatment (group 2, 15 patients). Patients were assessed at the 6-month followup by sexual history, physical examination, color Doppler sonography of the cavernous arteries and polisomnographic recording of nocturnal erections. Results: In group 1, 12 patients (80%) completed the entire treatment schedule and were evaluated at the long-term followup. Eight patients in this group (67%) reported the recovery of spontaneous erection sufficient for satisfactory sexual intercourse, compared with 3 patients (20%) in group 2. The difference between the 2 groups was statistically significant (p
| Original language | English |
|---|---|
| Pages (from-to) | 1408-1410 |
| Number of pages | 3 |
| Journal | Journal of Urology |
| Volume | 158 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 1997 |
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Keywords
- Alprostadil
- Penis
- Prostate
- Prostatectomy
ASJC Scopus subject areas
- Urology
Cite this
Recovery of spontaneous erectile function after nervesparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil : Results of a prospective, randomized trial. / Montorsi, Francesco; Guazzoni, Giorgio; Strambi, Luigi Ferini; Da Pozzo, Luigi F.; Nava, Luciano; Barbieri, Luigi; Rigatti, Patrizio; Pizzini, Giuliano; Miani, Alberto.
In: Journal of Urology, Vol. 158, No. 4, 10.1997, p. 1408-1410.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recovery of spontaneous erectile function after nervesparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil
T2 - Results of a prospective, randomized trial
AU - Montorsi, Francesco
AU - Guazzoni, Giorgio
AU - Strambi, Luigi Ferini
AU - Da Pozzo, Luigi F.
AU - Nava, Luciano
AU - Barbieri, Luigi
AU - Rigatti, Patrizio
AU - Pizzini, Giuliano
AU - Miani, Alberto
PY - 1997/10
Y1 - 1997/10
N2 - Purpose: This study was aimed at assessing prospectively the effect of postoperative intracavernous injections of alprostadil on the recovery of spontaneous erectile function after nervesparing radical retropubic prostatectomy. Materials and Methods: A total of 30 potent patients with clinically localized prostate cancer (clinical stage B1 or B2, Gleason sum 7 or greater, prostatic specific antigen less than 20 ng./ml.) underwent nerve- sparing radical retropubic prostatectomy and was subsequently randomized to alprostadil injections 3 times per week for 12 weeks (group 1, 15 patients) or observation without any erectogenic treatment (group 2, 15 patients). Patients were assessed at the 6-month followup by sexual history, physical examination, color Doppler sonography of the cavernous arteries and polisomnographic recording of nocturnal erections. Results: In group 1, 12 patients (80%) completed the entire treatment schedule and were evaluated at the long-term followup. Eight patients in this group (67%) reported the recovery of spontaneous erection sufficient for satisfactory sexual intercourse, compared with 3 patients (20%) in group 2. The difference between the 2 groups was statistically significant (p
AB - Purpose: This study was aimed at assessing prospectively the effect of postoperative intracavernous injections of alprostadil on the recovery of spontaneous erectile function after nervesparing radical retropubic prostatectomy. Materials and Methods: A total of 30 potent patients with clinically localized prostate cancer (clinical stage B1 or B2, Gleason sum 7 or greater, prostatic specific antigen less than 20 ng./ml.) underwent nerve- sparing radical retropubic prostatectomy and was subsequently randomized to alprostadil injections 3 times per week for 12 weeks (group 1, 15 patients) or observation without any erectogenic treatment (group 2, 15 patients). Patients were assessed at the 6-month followup by sexual history, physical examination, color Doppler sonography of the cavernous arteries and polisomnographic recording of nocturnal erections. Results: In group 1, 12 patients (80%) completed the entire treatment schedule and were evaluated at the long-term followup. Eight patients in this group (67%) reported the recovery of spontaneous erection sufficient for satisfactory sexual intercourse, compared with 3 patients (20%) in group 2. The difference between the 2 groups was statistically significant (p
KW - Alprostadil
KW - Penis
KW - Prostate
KW - Prostatectomy
UR - http://www.scopus.com/inward/record.url?scp=0030865724&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030865724&partnerID=8YFLogxK
U2 - 10.1016/S0022-5347(01)64227-7
DO - 10.1016/S0022-5347(01)64227-7
M3 - Article
VL - 158
SP - 1408
EP - 1410
JO - Journal of Urology
JF - Journal of Urology
SN - 0022-5347
IS - 4
ER -