Recovery of spontaneous erectile function after nervesparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: Results of a prospective, randomized trial

Francesco Montorsi, Giorgio Guazzoni, Luigi Ferini Strambi, Luigi F. Da Pozzo, Luciano Nava, Luigi Barbieri, Patrizio Rigatti, Giuliano Pizzini, Alberto Miani

Research output: Contribution to journalArticle

Abstract

Purpose: This study was aimed at assessing prospectively the effect of postoperative intracavernous injections of alprostadil on the recovery of spontaneous erectile function after nervesparing radical retropubic prostatectomy. Materials and Methods: A total of 30 potent patients with clinically localized prostate cancer (clinical stage B1 or B2, Gleason sum 7 or greater, prostatic specific antigen less than 20 ng./ml.) underwent nerve- sparing radical retropubic prostatectomy and was subsequently randomized to alprostadil injections 3 times per week for 12 weeks (group 1, 15 patients) or observation without any erectogenic treatment (group 2, 15 patients). Patients were assessed at the 6-month followup by sexual history, physical examination, color Doppler sonography of the cavernous arteries and polisomnographic recording of nocturnal erections. Results: In group 1, 12 patients (80%) completed the entire treatment schedule and were evaluated at the long-term followup. Eight patients in this group (67%) reported the recovery of spontaneous erection sufficient for satisfactory sexual intercourse, compared with 3 patients (20%) in group 2. The difference between the 2 groups was statistically significant (p

Original languageEnglish
Pages (from-to)1408-1410
Number of pages3
JournalJournal of Urology
Volume158
Issue number4
DOIs
Publication statusPublished - Oct 1997

Keywords

  • Alprostadil
  • Penis
  • Prostate
  • Prostatectomy

ASJC Scopus subject areas

  • Urology

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