Recruitment of circulating NK cells through decidual tissues: A possible mechanism controlling NK cell accumulation in the uterus during early pregnancy

Claudia Carlino, Helena Stabile, Stefania Morrone, Roberta Bulla, Alessandra Soriani, Chiara Agostinis, Fleur Bossi, Carlo Mocci, Filippo Sarazani, Francesco Tedesco, Angela Santoni, Angela Gismondi

Research output: Contribution to journalArticlepeer-review

Abstract

During early pregnancy, uterine mucosa decidualization is accompanied by a drastic enrichment of CD56highCD16 natural killer (NK) cells. Decidual NK (dNK) cells differ from peripheral blood NK (pbNK) cells in several ways, but their origin is still unclear. Our results demonstrate that chemokines present in the uterus can support pbNK cell migration through human endothelial and stromal decidual cells. Notably, we observed that pregnant women's pbNK cells are endowed with higher migratory ability compared with nonpregnant women's or male donors' pbNK cells. Moreover, NK cell migration through decidual stromal cells was increased when progesterone-cultured stromal cells were used as substrate, and this correlated with the ability of progesterone to up-regulate stromal cell chemokine expression. Furthermore, we demonstrate that dNK cells migrate through stromal cells using a distinct pattern of chemokines. Finally, we found that pbNK cells acquire a chemokine receptor pattern similar to that of dNK cells when they contact decidual stromal cells. Collectively these results strongly suggest that pbNK cell recruitment to the uterus contributes to the accumulation of NK cells during early pregnancy; that progesterone plays a crucial role in this event; and that pbNK cells undergo reprogramming of their chemokine receptor profile once exposed to uterine microenvironment.

Original languageEnglish
Pages (from-to)3108-3115
Number of pages8
JournalBlood
Volume111
Issue number6
DOIs
Publication statusPublished - Mar 15 2008

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Immunology
  • Hematology

Fingerprint Dive into the research topics of 'Recruitment of circulating NK cells through decidual tissues: A possible mechanism controlling NK cell accumulation in the uterus during early pregnancy'. Together they form a unique fingerprint.

Cite this