Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1

Laura Ciarlo, Rosa Vona, Valeria Manganelli, Lucrezia Gambardella, Carla Raggi, Matteo Marconi, Walter Malorni, Maurizio Sorice, Tina Garofalo, Paola Matarrese

Research output: Contribution to journalArticle

Abstract

The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid "rafts" in mitochondrial morphogenetic changes and their homeostasis.

Original languageEnglish
Pages (from-to)18869-18884
Number of pages16
JournalOncotarget
Volume9
Issue number27
DOIs
Publication statusPublished - Apr 10 2018

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Keywords

  • Apoptosis
  • Fusion
  • Lipid rafts
  • Mitochondria
  • Reactive oxygen species

ASJC Scopus subject areas

  • Oncology

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