Recurrence after marginal excision for atypical lipomatous tumors versus lipomas of the extremities

Costantino Errani, Stefania Cocchi, Nikolin Ali, Mohammadreza Chehrassan, Alberto Righi, Marco Gambarotti, Andreas F. Mavrogenis, Daniel Vanel, Davide Donati

Research output: Contribution to journalArticlepeer-review


This study reviewed the medical records of 90 patients with lipomas (47 patients) and atypical lipomatous tumors (ALT)/well-differentiated liposarcomas (WDL) (43 patients) of the extremities treated from 2006 to 2012. All patients had preoperative biopsy and postoperative histologic analysis of the tumors; surgical margins were marginal in all cases. Histologic sections of the tissue blocks from the excised specimens were re-reviewed for all patients; a consensus with postoperative histologic analysis was confirmed. Molecular chromosome analysis was performed on fluorescence in situ hybridization in tissue sections from the tissue blocks in all cases for the purpose of this study; a ratio greater than 2 was considered to represent murine double-minute 2 (MDM2) amplification consistent with a diagnosis of ALT/WDL. Mean follow-up was 52 months (range 14-96 months). Local recurrence and metastasis rates and the relationship of patient age and sex with tumor size and location were evaluated. None of the patients with lipomas experienced local recurrence compared with 6 patients (13.9%) with ALT/WDL who experienced local recurrence within a mean of 48 months (range 33-96 months); this difference was statistically significant. None of the patients in either group experienced metastasis prior to the study period. Local recurrence did not correlate statistically with patient age or sex or with tumor size or location.

Original languageEnglish
Pages (from-to)e610-e614
Number of pages5
Issue number4
Publication statusPublished - Jul 1 2016

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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