Recurrence of congenital heart disease in cases with familial risk screened prenatally by echocardiography.

Vlasta Fesslova, Jelena Brankovic, Faustina Lalatta, Laura Villa, Valerio Meli, Luciane Piazza, Cristian Ricci

Research output: Contribution to journalArticle

Abstract

To evaluate the recurrence of congenital heart disease (CHD) in pregnant women with familial risk who had been referred for fetal echocardiography. 1634 pregnancies from 1483 women with familial history of CHD in one or more relatives were studied. Fetal cardiologic diagnosis was compared with postnatal findings at 6 months or at autopsy. Total recurrence rate of CHD was 3.98%, 4.06% in single familial risk, 2.9% in double, and 5% in multiple risk. It was 3.5% in case of one previously affected child; 4.5% with 2 children; 5.2% with the mother alone affected and 7,5% with father alone affected and 3.5% with a single distant relative. Exact concordance of CHD was found in 21.5% and a partial concordance in 20% of cases. Our data show a higher recurrence rate of CHD than previously published data and high relative risk ratios compared to normal population.

Original languageEnglish
Pages (from-to)368067
Number of pages1
JournalJournal of Pregnancy
Volume2011
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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