Recurrence of Cushing's Disease in Childhood After Radiotherapy-Induced Remission

Marco Cappa, Elizabeth Stoner, Joan Dimartino Nardi, Songya Pang, Jean Temeck, Maria I. New

Research output: Contribution to journalArticle

Abstract

A 16-year-old female patient with recurrent Cushing's disease underwent successful treatment with pituitary irradiation. Within one year after radiotherapy, cortisol levels had returned to normal growth velocity improved, and puberty ensued. Five years after treatment, the patient developed clinical and biochemical evidence of recurrent CD. The high baseline evening corticotropin level was unresponsive to stimulation with ovine corticotropin-releasing hormone In patients with CD treated with radiotherapy, the corticotropin response to CRF stimulation may not be reliably compared with that of normal control values. After pituitary adenomectomy, the corticotropin concentration was still unresponsive to CRF. We suggest that the pituitary tumor was secondary to abnormal hypothalamic CRF regulation not corrected by pituitary irradiation; therefore, CD may recur despite pituitary irradiation.

Original languageEnglish
Pages (from-to)736-740
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume141
Issue number7
DOIs
Publication statusPublished - 1987

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Pituitary Irradiation
Pituitary ACTH Hypersecretion
Adrenocorticotropic Hormone
Radiotherapy
Recurrence
Corticotropin-Releasing Hormone
Pituitary Neoplasms
Puberty
Hydrocortisone
Sheep
Reference Values
Therapeutics
Growth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Recurrence of Cushing's Disease in Childhood After Radiotherapy-Induced Remission. / Cappa, Marco; Stoner, Elizabeth; Dimartino Nardi, Joan; Pang, Songya; Temeck, Jean; New, Maria I.

In: American Journal of Diseases of Children, Vol. 141, No. 7, 1987, p. 736-740.

Research output: Contribution to journalArticle

Cappa, Marco ; Stoner, Elizabeth ; Dimartino Nardi, Joan ; Pang, Songya ; Temeck, Jean ; New, Maria I. / Recurrence of Cushing's Disease in Childhood After Radiotherapy-Induced Remission. In: American Journal of Diseases of Children. 1987 ; Vol. 141, No. 7. pp. 736-740.
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