Recurrence of Ph'-positive leukemia in donor cells after marrow transplantation for chronic granulocytic leukemia

A. Marmont, F. Frassoni, A. Bacigalupo, M. Podestá, G. Piaggio, M. T. Van Lint, A. Caimo, S. de Filippi

Research output: Contribution to journalArticle

Abstract

The recurrence of leukemia in donor cells is a rare type of relapse after bone-marrow transplantation for acute leukemia, whether lymphoblastic or nonlymphoblastic. This phenomenon was first described in 1971, and since then additional cases have been reported - two of nonlymphoblastic and five of lymphoblastic leukemia. Disease recurred in the original cell line in five cases, and in morphologically different lines in two; all the patients were either in relapse or in an advanced stage of disease at the time of transplantation. The authors report a case of Ph' (Philadelphia cromosome)-positive leukemic relapse in donor cells after allogeneic marrow transplantation for Ph'-positive chronic granulocytic leukemia in a second chronic phase.

Original languageEnglish
Pages (from-to)903-906
Number of pages4
JournalNew England Journal of Medicine
Volume310
Issue number14
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Medicine(all)

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