Recurrences in the Blanking Period and 12-Month Success Rate by Continuous Cardiac Monitoring After Cryoablation of Paroxysmal and Non-Paroxysmal Atrial Fibrillation

Paolo Pieragnoli, Alessandro Paoletti Perini, Giuseppe Ricciardi, Luca Checchi, Andrea Giomi, Iacopo Muraca, Letizia Mannucci, Luigi Padeletti

Research output: Contribution to journalArticle

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Abstract

Introduction: Recurrences within the blanking period (early recurrences) are common after atrial fibrillation (AF) ablation by pulmonary vein isolation (PVI), but their clinical significance is still controversial. We aimed at evaluating the significance of within-blanking recurrences at 12-month follow-up after cryoballoon (CB) PVI, and to assess the real procedural success rate by continuous monitoring of cardiac rhythm. Methods and Results: Sixty consecutive AF patients (34 paroxysmal, 56.7%) underwent their first CB-PVI at one Italian center (May 2013 to April 2015), and subsequent implantation of an implantable loop recorder (ILR). Overall, 12-month success rate after the blanking period was 55%. The shortest detected event was 7 minutes long. Late recurrences were more frequent in non-paroxysmal (19/26, 73.1%) than in paroxysmal AF (8/34, 23.5%; P <0.001). Early recurrences occurred in 17 (28.3%) patients, with 14 also having late recurrences (82.3%), while only 13 out of 43 (30.2%) without within-blanking recurrences experienced post-blanking events (P <0.001). Overall, early recurrences showed 51.8% sensitivity (95% CI 31.9–71.3%) and 90.9% specificity (95% CI 75.7–98.1%) for later recurrences, with 82.3% (95% CI 56.6–96.2%) positive and 69.8% (95% CI 53.9–82.8%) negative predictive value. The positive likelihood ratio was 5.7 (95% CI 1.8–17.8). At multivariable analysis, non-paroxysmal AF (HR: 3.113; 95% CI 1.309–7.403; P = 0.010) and within-blanking recurrences (HR: 3.453; 95% CI 1.544–7.722; P = 0.003) were independent predictors of post-blanking AT/AF. Conclusion: CB-PVI for paroxysmal AF shows a 12-month success rate of 76.5% after one single procedure, as assessed by continuous cardiac rhythm monitoring. Within-blanking recurrences predict the ablation failure in more than 80% of patients.

Original languageEnglish
Pages (from-to)625-633
Number of pages9
JournalJournal of Cardiovascular Electrophysiology
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

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Cryosurgery
Atrial Fibrillation
Recurrence
Pulmonary Veins

Keywords

  • blanking period
  • cryoballoon ablation
  • early recurrence
  • implantable loop recorder
  • late recurrence
  • paroxysmal atrial fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Recurrences in the Blanking Period and 12-Month Success Rate by Continuous Cardiac Monitoring After Cryoablation of Paroxysmal and Non-Paroxysmal Atrial Fibrillation. / Pieragnoli, Paolo; Paoletti Perini, Alessandro; Ricciardi, Giuseppe; Checchi, Luca; Giomi, Andrea; Muraca, Iacopo; Mannucci, Letizia; Padeletti, Luigi.

In: Journal of Cardiovascular Electrophysiology, Vol. 28, No. 6, 01.06.2017, p. 625-633.

Research output: Contribution to journalArticle

Pieragnoli, Paolo ; Paoletti Perini, Alessandro ; Ricciardi, Giuseppe ; Checchi, Luca ; Giomi, Andrea ; Muraca, Iacopo ; Mannucci, Letizia ; Padeletti, Luigi. / Recurrences in the Blanking Period and 12-Month Success Rate by Continuous Cardiac Monitoring After Cryoablation of Paroxysmal and Non-Paroxysmal Atrial Fibrillation. In: Journal of Cardiovascular Electrophysiology. 2017 ; Vol. 28, No. 6. pp. 625-633.
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abstract = "Introduction: Recurrences within the blanking period (early recurrences) are common after atrial fibrillation (AF) ablation by pulmonary vein isolation (PVI), but their clinical significance is still controversial. We aimed at evaluating the significance of within-blanking recurrences at 12-month follow-up after cryoballoon (CB) PVI, and to assess the real procedural success rate by continuous monitoring of cardiac rhythm. Methods and Results: Sixty consecutive AF patients (34 paroxysmal, 56.7{\%}) underwent their first CB-PVI at one Italian center (May 2013 to April 2015), and subsequent implantation of an implantable loop recorder (ILR). Overall, 12-month success rate after the blanking period was 55{\%}. The shortest detected event was 7 minutes long. Late recurrences were more frequent in non-paroxysmal (19/26, 73.1{\%}) than in paroxysmal AF (8/34, 23.5{\%}; P <0.001). Early recurrences occurred in 17 (28.3{\%}) patients, with 14 also having late recurrences (82.3{\%}), while only 13 out of 43 (30.2{\%}) without within-blanking recurrences experienced post-blanking events (P <0.001). Overall, early recurrences showed 51.8{\%} sensitivity (95{\%} CI 31.9–71.3{\%}) and 90.9{\%} specificity (95{\%} CI 75.7–98.1{\%}) for later recurrences, with 82.3{\%} (95{\%} CI 56.6–96.2{\%}) positive and 69.8{\%} (95{\%} CI 53.9–82.8{\%}) negative predictive value. The positive likelihood ratio was 5.7 (95{\%} CI 1.8–17.8). At multivariable analysis, non-paroxysmal AF (HR: 3.113; 95{\%} CI 1.309–7.403; P = 0.010) and within-blanking recurrences (HR: 3.453; 95{\%} CI 1.544–7.722; P = 0.003) were independent predictors of post-blanking AT/AF. Conclusion: CB-PVI for paroxysmal AF shows a 12-month success rate of 76.5{\%} after one single procedure, as assessed by continuous cardiac rhythm monitoring. Within-blanking recurrences predict the ablation failure in more than 80{\%} of patients.",
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T1 - Recurrences in the Blanking Period and 12-Month Success Rate by Continuous Cardiac Monitoring After Cryoablation of Paroxysmal and Non-Paroxysmal Atrial Fibrillation

AU - Pieragnoli, Paolo

AU - Paoletti Perini, Alessandro

AU - Ricciardi, Giuseppe

AU - Checchi, Luca

AU - Giomi, Andrea

AU - Muraca, Iacopo

AU - Mannucci, Letizia

AU - Padeletti, Luigi

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Introduction: Recurrences within the blanking period (early recurrences) are common after atrial fibrillation (AF) ablation by pulmonary vein isolation (PVI), but their clinical significance is still controversial. We aimed at evaluating the significance of within-blanking recurrences at 12-month follow-up after cryoballoon (CB) PVI, and to assess the real procedural success rate by continuous monitoring of cardiac rhythm. Methods and Results: Sixty consecutive AF patients (34 paroxysmal, 56.7%) underwent their first CB-PVI at one Italian center (May 2013 to April 2015), and subsequent implantation of an implantable loop recorder (ILR). Overall, 12-month success rate after the blanking period was 55%. The shortest detected event was 7 minutes long. Late recurrences were more frequent in non-paroxysmal (19/26, 73.1%) than in paroxysmal AF (8/34, 23.5%; P <0.001). Early recurrences occurred in 17 (28.3%) patients, with 14 also having late recurrences (82.3%), while only 13 out of 43 (30.2%) without within-blanking recurrences experienced post-blanking events (P <0.001). Overall, early recurrences showed 51.8% sensitivity (95% CI 31.9–71.3%) and 90.9% specificity (95% CI 75.7–98.1%) for later recurrences, with 82.3% (95% CI 56.6–96.2%) positive and 69.8% (95% CI 53.9–82.8%) negative predictive value. The positive likelihood ratio was 5.7 (95% CI 1.8–17.8). At multivariable analysis, non-paroxysmal AF (HR: 3.113; 95% CI 1.309–7.403; P = 0.010) and within-blanking recurrences (HR: 3.453; 95% CI 1.544–7.722; P = 0.003) were independent predictors of post-blanking AT/AF. Conclusion: CB-PVI for paroxysmal AF shows a 12-month success rate of 76.5% after one single procedure, as assessed by continuous cardiac rhythm monitoring. Within-blanking recurrences predict the ablation failure in more than 80% of patients.

AB - Introduction: Recurrences within the blanking period (early recurrences) are common after atrial fibrillation (AF) ablation by pulmonary vein isolation (PVI), but their clinical significance is still controversial. We aimed at evaluating the significance of within-blanking recurrences at 12-month follow-up after cryoballoon (CB) PVI, and to assess the real procedural success rate by continuous monitoring of cardiac rhythm. Methods and Results: Sixty consecutive AF patients (34 paroxysmal, 56.7%) underwent their first CB-PVI at one Italian center (May 2013 to April 2015), and subsequent implantation of an implantable loop recorder (ILR). Overall, 12-month success rate after the blanking period was 55%. The shortest detected event was 7 minutes long. Late recurrences were more frequent in non-paroxysmal (19/26, 73.1%) than in paroxysmal AF (8/34, 23.5%; P <0.001). Early recurrences occurred in 17 (28.3%) patients, with 14 also having late recurrences (82.3%), while only 13 out of 43 (30.2%) without within-blanking recurrences experienced post-blanking events (P <0.001). Overall, early recurrences showed 51.8% sensitivity (95% CI 31.9–71.3%) and 90.9% specificity (95% CI 75.7–98.1%) for later recurrences, with 82.3% (95% CI 56.6–96.2%) positive and 69.8% (95% CI 53.9–82.8%) negative predictive value. The positive likelihood ratio was 5.7 (95% CI 1.8–17.8). At multivariable analysis, non-paroxysmal AF (HR: 3.113; 95% CI 1.309–7.403; P = 0.010) and within-blanking recurrences (HR: 3.453; 95% CI 1.544–7.722; P = 0.003) were independent predictors of post-blanking AT/AF. Conclusion: CB-PVI for paroxysmal AF shows a 12-month success rate of 76.5% after one single procedure, as assessed by continuous cardiac rhythm monitoring. Within-blanking recurrences predict the ablation failure in more than 80% of patients.

KW - blanking period

KW - cryoballoon ablation

KW - early recurrence

KW - implantable loop recorder

KW - late recurrence

KW - paroxysmal atrial fibrillation

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