Aim. Meningiomas, histologically benign tumours, may sometimes show a discrepancy between morphology and biological behaviour, showing recurrences and proliferative foci, which make the definition of grading difficult. In this study we investigated the utility of indicators of cell proliferation for a better definition of biological behaviour of recurrent atypical benign meningiomas. Materials and methods. Fifty syncitial, 50 atypical and 8 primary benign meningiomas with their recurrences were studied. Nuclear antigen Ki67LI, DNA-Feulgen positivity and nucleolar antigen AgNOR were evaluated and the results calculated and elaborated by computerized image analyzer Vidas Kontron Elektronik Zeiss. Results. The Ki67LI was 11.3% in typical meningiomas, 13.6% in primary meningiomas, 26.6% in atypical and 28.2% in recurrent meningiomas. The AgNOR granule count showed that typical and primary meningiomas had a mean value of 1.51-1.49, whereas recurring and atypical meningiomas had a mean of 1.92 and 1.98. The DNA-ploidy revealed, in the hyperpolyploid region between 4c-16c, 7.02% of the nuclei in primary meningiomas, 17.98% in recurring and 24.63% in atypical. Conclusion. Our results suggest that the evaluation of cell proliferation using Ki67LI, DNA ploidy and AgNOR, integrated with standard histopathology, can provide useful information for a correct grading of meningiomas.
|Translated title of the contribution||Recurrent and atypical meningiomas. A multiparametric study using Ki67 labelling index, AgNOR and DNA-Feulgen staining|
|Number of pages||5|
|Journal||European Journal of Oncology|
|Publication status||Published - Sep 2002|
ASJC Scopus subject areas
- Cancer Research