Néphrolithiases récurrentes de brushite révélant une hyperparathyroïdie primaire

Translated title of the contribution: Recurrent episodes of brushite nephrolithiasis revealing primary hyperparathyroidism

I. Simon, T. Roumeguère, F. Devuyst, F. Cotton, B. N T Tang, M. Cappello, S. Corbetta, M. Idrissi, A. Pozdzik, J. Nortier

Research output: Contribution to journalArticlepeer-review


Introduction: Nephrolithiasis is a frequent disease observed in 1 to 20 % of the general population. This disease predominates in male patients (2:1) and is characterized by a high rate of recurrences (about 50 %). Case report: We report the case of a 45-year old male patient who experienced during about ten years recurrent bilateral renal colic episodes due to brushite lithiasis. These stones were treated with multiple extracorporeal shock wave lithotripsy sessions. A pyeloureteral junction syndrome predisposing to bulky stones formation has been put in evidence and required a pyeloplasty. After more than ten years of disease activity, a biochemical screening diagnosed primary hyperparathyroidism (PHPT). Radiological assessment identified a parathyroid gland adenoma. Successful surgical removal of this lesion was followed by resolution of the symptomatic kidney stones formation. Discussion: PHPT is associated with kidney stones in about 20 % of the patients. Hypercalciuria is the main risk factor of stones formation but other predisposing factors are also probably involved. Patients carrying a polymorphism located in the coding sequence of the calcium-sensing receptor gene or in the regulatory region of this gene seem to experience an increased occurrence of urinary lithiasis. Conclusion: The present case stresses the impor tance of a metabolic assessment in all patients with recurrent nephrolithiasis, especially in case of bilateral episodes.

Translated title of the contributionRecurrent episodes of brushite nephrolithiasis revealing primary hyperparathyroidism
Original languageFrench
Pages (from-to)172-176
Number of pages5
JournalRevue Medicale de Bruxelles
Issue number3
Publication statusPublished - Jun 1 2015


  • Calcium-sensing receptor
  • Hypercalciuria
  • Nephrolithiasis
  • Primary hyperparathyroidism

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Recurrent episodes of brushite nephrolithiasis revealing primary hyperparathyroidism'. Together they form a unique fingerprint.

Cite this