Introduction: Nephrolithiasis is a frequent disease observed in 1 to 20 % of the general population. This disease predominates in male patients (2:1) and is characterized by a high rate of recurrences (about 50 %). Case report: We report the case of a 45-year old male patient who experienced during about ten years recurrent bilateral renal colic episodes due to brushite lithiasis. These stones were treated with multiple extracorporeal shock wave lithotripsy sessions. A pyeloureteral junction syndrome predisposing to bulky stones formation has been put in evidence and required a pyeloplasty. After more than ten years of disease activity, a biochemical screening diagnosed primary hyperparathyroidism (PHPT). Radiological assessment identified a parathyroid gland adenoma. Successful surgical removal of this lesion was followed by resolution of the symptomatic kidney stones formation. Discussion: PHPT is associated with kidney stones in about 20 % of the patients. Hypercalciuria is the main risk factor of stones formation but other predisposing factors are also probably involved. Patients carrying a polymorphism located in the coding sequence of the calcium-sensing receptor gene or in the regulatory region of this gene seem to experience an increased occurrence of urinary lithiasis. Conclusion: The present case stresses the impor tance of a metabolic assessment in all patients with recurrent nephrolithiasis, especially in case of bilateral episodes.
|Translated title of the contribution||Recurrent episodes of brushite nephrolithiasis revealing primary hyperparathyroidism|
|Number of pages||5|
|Journal||Revue Medicale de Bruxelles|
|Publication status||Published - Jun 1 2015|
- Calcium-sensing receptor
- Primary hyperparathyroidism
ASJC Scopus subject areas