Abstract
HLA supratypes as well as serum IgG, IgA and IgM levels were determined in 44 children and adolescents with severe IgA deficiency (serum IgA -4) preferentially associated with A33, A28 or A blank. The supratype B14, BfS, C4A2, C4B2, DR1, DQW1 was present in a 14-fold higher frequency than in the controls, and strongly suggests the presence of a gene in the HLA region involved in the deficiency of IgA. The fact that this supratype was not always associated with IgA deficiency in the parents and that not all IgA-deficient subjects had this supratype is discussed. Severe IgA deficiency was found in four mothers (two of the four mother-child pairs shared the B14, DR1 haplotype); three other relatives (one father and two brothers) had partial IgA deficiency and did not have the B14, DR1, DQW1 haplotype.
| Original language | English |
|---|---|
| Pages (from-to) | 127-132 |
| Number of pages | 6 |
| Journal | Tissue Antigens |
| Volume | 34 |
| Issue number | 2 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Cell Biology
- Immunology
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Recurrent extended HLA haplotypes in children with selective IgA deficiency. / Cuccia-Belvedere, M.; Monafo, V.; Martinetti, M.; Plebani, A.; De Paoli, F.; Burgio, G. R.
In: Tissue Antigens, Vol. 34, No. 2, 1989, p. 127-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recurrent extended HLA haplotypes in children with selective IgA deficiency
AU - Cuccia-Belvedere, M.
AU - Monafo, V.
AU - Martinetti, M.
AU - Plebani, A.
AU - De Paoli, F.
AU - Burgio, G. R.
PY - 1989
Y1 - 1989
N2 - HLA supratypes as well as serum IgG, IgA and IgM levels were determined in 44 children and adolescents with severe IgA deficiency (serum IgA -4) preferentially associated with A33, A28 or A blank. The supratype B14, BfS, C4A2, C4B2, DR1, DQW1 was present in a 14-fold higher frequency than in the controls, and strongly suggests the presence of a gene in the HLA region involved in the deficiency of IgA. The fact that this supratype was not always associated with IgA deficiency in the parents and that not all IgA-deficient subjects had this supratype is discussed. Severe IgA deficiency was found in four mothers (two of the four mother-child pairs shared the B14, DR1 haplotype); three other relatives (one father and two brothers) had partial IgA deficiency and did not have the B14, DR1, DQW1 haplotype.
AB - HLA supratypes as well as serum IgG, IgA and IgM levels were determined in 44 children and adolescents with severe IgA deficiency (serum IgA -4) preferentially associated with A33, A28 or A blank. The supratype B14, BfS, C4A2, C4B2, DR1, DQW1 was present in a 14-fold higher frequency than in the controls, and strongly suggests the presence of a gene in the HLA region involved in the deficiency of IgA. The fact that this supratype was not always associated with IgA deficiency in the parents and that not all IgA-deficient subjects had this supratype is discussed. Severe IgA deficiency was found in four mothers (two of the four mother-child pairs shared the B14, DR1 haplotype); three other relatives (one father and two brothers) had partial IgA deficiency and did not have the B14, DR1, DQW1 haplotype.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024444890&partnerID=8YFLogxK
M3 - Article
C2 - 2609322
AN - SCOPUS:0024444890
VL - 34
SP - 127
EP - 132
JO - Tissue Antigens
JF - Tissue Antigens
SN - 0001-2815
IS - 2
ER -