TY - JOUR
T1 - Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin
AU - Martini, Alberto
AU - Ravelli, Angelo
AU - Albani, Salvatore
AU - Viola, Stefania
AU - Scotta, M. Serenella
AU - Magrini, Umberto
AU - Burgio, G. Roberto
PY - 1992
Y1 - 1992
N2 - An adult patient had a syndrome associating the features of juvenile dermatomyositis and cutaneous polyarteritis nodosa that followed a cyclic course from childhood; recurrences were always associated with a rise of serum antistreptococcal antibodies. Regions of homology between streptococcal type 5 M protein and skeletal myosin were found. These findings suggest that streptococcal infection, possibly through a molecular mimicry mechanism, played a role in the pathogenesis of the disease in our patient.
AB - An adult patient had a syndrome associating the features of juvenile dermatomyositis and cutaneous polyarteritis nodosa that followed a cyclic course from childhood; recurrences were always associated with a rise of serum antistreptococcal antibodies. Regions of homology between streptococcal type 5 M protein and skeletal myosin were found. These findings suggest that streptococcal infection, possibly through a molecular mimicry mechanism, played a role in the pathogenesis of the disease in our patient.
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U2 - 10.1016/S0022-3476(05)81905-5
DO - 10.1016/S0022-3476(05)81905-5
M3 - Article
C2 - 1359045
AN - SCOPUS:0026451486
VL - 121
SP - 739
EP - 742
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 5 PART 1
ER -