Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin

Alberto Martini; Angelo Ravelli; Salvatore Albani; Stefania Viola; M. Serenella Scotta; Umberto Magrini; G. Roberto Burgio

doi:10.1016/S0022-3476(05)81905-5

Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin

Alberto Martini, Angelo Ravelli, Salvatore Albani, Stefania Viola, M. Serenella Scotta, Umberto Magrini, G. Roberto Burgio

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

An adult patient had a syndrome associating the features of juvenile dermatomyositis and cutaneous polyarteritis nodosa that followed a cyclic course from childhood; recurrences were always associated with a rise of serum antistreptococcal antibodies. Regions of homology between streptococcal type 5 M protein and skeletal myosin were found. These findings suggest that streptococcal infection, possibly through a molecular mimicry mechanism, played a role in the pathogenesis of the disease in our patient.

Original language	English
Pages (from-to)	739-742
Number of pages	4
Journal	Journal of Pediatrics
Volume	121
Issue number	5 PART 1
DOIs	https://doi.org/10.1016/S0022-3476(05)81905-5
Publication status	Published - 1992

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Access to Document

10.1016/S0022-3476(05)81905-5

Fingerprint Dive into the research topics of 'Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin'. Together they form a unique fingerprint.

Cite this

Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin. / Martini, Alberto ; Ravelli, Angelo; Albani, Salvatore; Viola, Stefania; Scotta, M. Serenella; Magrini, Umberto; Burgio, G. Roberto.

In: Journal of Pediatrics, Vol. 121, No. 5 PART 1, 1992, p. 739-742.

Research output: Contribution to journal › Article › peer-review

Martini, Alberto ; Ravelli, Angelo ; Albani, Salvatore ; Viola, Stefania ; Scotta, M. Serenella ; Magrini, Umberto ; Burgio, G. Roberto. / Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin. In: Journal of Pediatrics. 1992 ; Vol. 121, No. 5 PART 1. pp. 739-742.

@article{89d7230077cb4c76915a9004256e0485,

title = "Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin",

abstract = "An adult patient had a syndrome associating the features of juvenile dermatomyositis and cutaneous polyarteritis nodosa that followed a cyclic course from childhood; recurrences were always associated with a rise of serum antistreptococcal antibodies. Regions of homology between streptococcal type 5 M protein and skeletal myosin were found. These findings suggest that streptococcal infection, possibly through a molecular mimicry mechanism, played a role in the pathogenesis of the disease in our patient.",

author = "Alberto Martini and Angelo Ravelli and Salvatore Albani and Stefania Viola and Scotta, {M. Serenella} and Umberto Magrini and Burgio, {G. Roberto}",

year = "1992",

doi = "10.1016/S0022-3476(05)81905-5",

language = "English",

volume = "121",

pages = "739--742",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

number = "5 PART 1",

}

TY - JOUR

T1 - Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin

AU - Martini, Alberto

AU - Ravelli, Angelo

AU - Albani, Salvatore

AU - Viola, Stefania

AU - Scotta, M. Serenella

AU - Magrini, Umberto

AU - Burgio, G. Roberto

PY - 1992

Y1 - 1992

N2 - An adult patient had a syndrome associating the features of juvenile dermatomyositis and cutaneous polyarteritis nodosa that followed a cyclic course from childhood; recurrences were always associated with a rise of serum antistreptococcal antibodies. Regions of homology between streptococcal type 5 M protein and skeletal myosin were found. These findings suggest that streptococcal infection, possibly through a molecular mimicry mechanism, played a role in the pathogenesis of the disease in our patient.

AB - An adult patient had a syndrome associating the features of juvenile dermatomyositis and cutaneous polyarteritis nodosa that followed a cyclic course from childhood; recurrences were always associated with a rise of serum antistreptococcal antibodies. Regions of homology between streptococcal type 5 M protein and skeletal myosin were found. These findings suggest that streptococcal infection, possibly through a molecular mimicry mechanism, played a role in the pathogenesis of the disease in our patient.

UR - http://www.scopus.com/inward/record.url?scp=0026451486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026451486&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(05)81905-5

DO - 10.1016/S0022-3476(05)81905-5

M3 - Article

C2 - 1359045

AN - SCOPUS:0026451486

VL - 121

SP - 739

EP - 742

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 5 PART 1

ER -