Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin

Alberto Martini, Angelo Ravelli, Salvatore Albani, Stefania Viola, M. Serenella Scotta, Umberto Magrini, G. Roberto Burgio

Research output: Contribution to journalArticlepeer-review

Abstract

An adult patient had a syndrome associating the features of juvenile dermatomyositis and cutaneous polyarteritis nodosa that followed a cyclic course from childhood; recurrences were always associated with a rise of serum antistreptococcal antibodies. Regions of homology between streptococcal type 5 M protein and skeletal myosin were found. These findings suggest that streptococcal infection, possibly through a molecular mimicry mechanism, played a role in the pathogenesis of the disease in our patient.

Original languageEnglish
Pages (from-to)739-742
Number of pages4
JournalJournal of Pediatrics
Volume121
Issue number5 PART 1
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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